A new anticancer dihydroflavanoid from the root of Spiranthes australis (R. Brown) Lindl.

Abstract

A new dihydroflavanoid was obtained from the root of Spiranthes australis (R. Brown) Lindl, a traditional Chinese medicinal herb. The structure was elucidated as (2S)-5,2',6'-trihydroxy-6-lavandulyl-4''-(gamma,gamma-dimethylallyl)-2'',2''-dimethylpyrano-[5'',6'' : 7,8]-flavanone by spectroscopic methods including UV, IR, HR-EI-MS, ESI-MS, 1D NMR and 2D NMR techniques, and subsequently, the anticancer activities of the compound to inhibit human cancer cells' growth including A549, BEL-7402, SGC-7901, MCF-7, HT-29, K562, and A498 cell lines by MTT method was evaluated in vitro.

• Authors: Jinyong Peng, Qiwei Xu, Youwei Xu, Yan Qi, Xu Han, Lina Xu
• Journal: Natural product research (Nat Prod Res) Vol. 21 Issue 7 Pg. 641-5 (Jun 2007) ISSN: 1478-6419 [Print] England
• PMID: 17613822 (Publication Type: Journal Article)

Chemical References

• Antineoplastic Agents, Phytogenic
• Flavonoids
• Formazans
• Tetrazolium Salts
• MTT formazan

Topics

• Antineoplastic Agents, Phytogenic (chemistry, isolation & purification, pharmacology)
• Cell Survival (drug effects)
• Drug Screening Assays, Antitumor
• Flavonoids (chemistry, isolation & purification, pharmacology)
• Formazans (chemistry)
• HT29 Cells
• Humans
• Inhibitory Concentration 50
• K562 Cells
• Mass Spectrometry
• Nuclear Magnetic Resonance, Biomolecular
• Orchidaceae (chemistry)
• Plant Roots (chemistry)
• Plants, Medicinal (chemistry)
• Spectrophotometry, Infrared
• Spectrophotometry, Ultraviolet
• Tetrazolium Salts (chemistry)