Abstract |
Photodynamic therapy ( PDT) with 5-aminolaevulinic acid (ALA) is a novel treatment for high-grade dysplasia (HGD) in Barrett's esophagus (BE). Our aim was to evaluate the effectiveness of differing light doses. Patients with HGD in BE received oral ALA (60 mg/kg) activated by low (500 J/cm), medium (750 J/cm), high (1,000 J/cm), or highest (1,000 J/cm x2) light dose at 635 nm. Follow-up was by regular endoscopy with quadrantic biopsies. Twenty-four patients were treated. Successful eradication of HGD was significantly correlated with light dose (log rank, p < 0.01). Six of eight patients (75%) treated with the highest light dose, one of two treated with high dose (50%), two of nine (22%) receiving medium light dose, and zero of five receiving low light dose had successful eradication of HGD (median follow-up 45 months, range 1-78 months). No skin photosensitivity or esophageal strictures occurred. The efficacy of ALA- PDT for eradication of HGD in BE is closely related to the light dose used. With a drug dose of 60 mg/kg and light at 635 nm, we recommend a minimum light dose of 1,000 J/cm of esophagus. This dose appears safe.
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Authors | Gary D Mackenzie, Neil F Jamieson, Marco R Novelli, C Alexander Mosse, Benjamin R Clark, Sally M Thorpe, Stephen G Bown, Laurence B Lovat |
Journal | Lasers in medical science
(Lasers Med Sci)
Vol. 23
Issue 2
Pg. 203-10
(Apr 2008)
ISSN: 0268-8921 [Print] England |
PMID | 17610005
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Photosensitizing Agents
- Aminolevulinic Acid
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Topics |
- Aged
- Aged, 80 and over
- Aminolevulinic Acid
(administration & dosage, therapeutic use)
- Barrett Esophagus
(pathology, therapy)
- Dose-Response Relationship, Radiation
- Female
- Humans
- Laser Therapy
(adverse effects, instrumentation, methods)
- Light
- Male
- Middle Aged
- Photochemotherapy
(instrumentation, methods)
- Photosensitizing Agents
(administration & dosage, therapeutic use)
- Prospective Studies
- Treatment Outcome
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