Abstract | BACKGROUND: METHODS: Using an orthotopic liver transplantation model, the effects on rat liver preservation of a modified preservation solution (UW-PEG) were evaluated, based on the inversion of K(+) and Na(+) concentration and the replacement of HES by PEG 35 kDa (0.03 mmol/L) in UW preservation solution. RESULTS: The use of UW-PEG preservation solution ameliorated the biochemical and histological parameters of hepatic damage. Thus, at 24 h after transplantation, transaminase levels were reduced significantly when livers were preserved during 8 h in UW-PEG preservation solution compared with the original UW solution. In addition, histological findings revealed fewer and smaller areas of hepatocyte necrosis. The benefits of UW-PEG solution cannot be explained by modifications in oxidative stress or neutrophil accumulation associated with liver transplantation. However, the results of hepatic and portal blood flow indicated that the benefits of this modified preservation solution, UW-PEG were associated with improvements in the microcirculatory disorders after reperfusion. CONCLUSIONS:
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Authors | Rosa Franco-Gou, Ismail Ben Mosbah, Anna Serafin, Hassen Ben Abdennebi, Joan Roselló-Catafau, Carmen Peralta |
Journal | Journal of gastroenterology and hepatology
(J Gastroenterol Hepatol)
Vol. 22
Issue 7
Pg. 1120-6
(Jul 2007)
ISSN: 0815-9319 [Print] Australia |
PMID | 17608858
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Organ Preservation Solutions
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Topics |
- Animals
- Cold Ischemia
(adverse effects)
- Liver Transplantation
- Organ Preservation
(methods)
- Organ Preservation Solutions
- Rats
- Rats, Sprague-Dawley
- Reperfusion Injury
(prevention & control)
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