Abstract | BACKGROUND:
Hidradenitis suppurativa (HS) is a recurrent disease confined to apocrine gland-bearing areas causing painful, deep-seated lesions and draining sinus tracts. Uniformly effective therapy is lacking. Improvements in current medical management strategies are needed. OBJECTIVE: We sought to determine the success rate for a variety of treatments in our female HS patients and whether androgen-related tests can predict a response to antiandrogen therapy. As HS has been linked to a hyperandrogen state, we sought to determine if it is also associated with polycystic ovary syndrome (PCOS). METHODS: A retrospective chart review was performed examining hormonal profiles and the response to a variety of treatments in female patients with HS. RESULTS: Sixty-four female HS patients were identified (mean age 33 years). Antiandrogen therapy was superior to oral antibiotic therapy (55% vs 26%) based on a two-sample, two-sided, t-test statistic (p < .04). The prevalence of PCOS among our study patients in whom androgen markers were available was 8 of 21 (38.1%), and even if taken over all study patients, not necessarily investigated for PCOS, the prevalence was 8 of 64 (12.5%). This reflects a greater than expected prevalence among all women (10%). CONCLUSION: As a proof-of-concept study, despite limitations inherent in a retrospective chart review, there is sufficient signal to suggest that a hormonal manipulation approach to therapy should be considered in all women presenting with HS. Female patients presenting with HS should prompt investigations for underlying PCOS and insulin resistance.
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Authors | John N Kraft, Gordon E Searles |
Journal | Journal of cutaneous medicine and surgery
(J Cutan Med Surg)
2007 Jul-Aug
Vol. 11
Issue 4
Pg. 125-31
ISSN: 1203-4754 [Print] United States |
PMID | 17601419
(Publication Type: Journal Article)
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Chemical References |
- Androgen Antagonists
- Anti-Bacterial Agents
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Topics |
- Administration, Oral
- Adolescent
- Adult
- Aged
- Androgen Antagonists
(therapeutic use)
- Anti-Bacterial Agents
(administration & dosage)
- Child
- Drug Therapy, Combination
- Female
- Hidradenitis Suppurativa
(drug therapy)
- Humans
- Middle Aged
- Retrospective Studies
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