Topical pranoprofen 0.1% is as effective anti-inflammatory and analgesic agent as diclofenac sodium 0.1% after strabismus surgery.

Abstract	To compare the anti-inflammatory and analgesic effects of topical pranoprofen 0.1% with diclofenac sodium 0.1% after strabismus surgery, 40 patients were prospectively randomized and assigned into 2 groups. Signs and symptoms of inflammation, as well as intraocular pressure (IOP) of patients, were evaluated at 1 day and 1 and 3 weeks following surgery. Both groups reported reduced inflammation and discomfort at 1 week, as compared to 1 day. There was no statistically significant difference in any measurement of postoperative inflammation (i.e., discomfort, chemosis, secretion, conjunctival hyperemia, and conjunctival gap size) between the 2 groups at any time. None of the patients developed an allergic reaction to the medications and IOP measurements were within the normal limits in both groups. Pranoprofen 0.1% was found to be as effective as diclofenac sodium 0.1% in reducing inflammation and pain after strabismus surgery. Pranoprofen could be used as a safe and effective anti-inflammatory alternative for the treatment of inflammation following strabismus surgery.
Authors	Ilknur Akyol-Salman, Deniz Leçe-Sertöz, Orhan Baykal
Journal	Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics (J Ocul Pharmacol Ther) Vol. 23 Issue 3 Pg. 280-3 (Jun 2007) ISSN: 1080-7683 [Print] United States
PMID	17593012 (Publication Type: Comparative Study, Journal Article, Randomized Controlled Trial)
Chemical References	Anti-Inflammatory Agents, Non-Steroidal Benzopyrans Ophthalmic Solutions Propionates Diclofenac pyranoprofen
Topics	Administration, Topical Adolescent Adult Anti-Inflammatory Agents, Non-Steroidal (adverse effects, therapeutic use) Benzopyrans (adverse effects, therapeutic use) Child Child, Preschool Diclofenac (adverse effects, therapeutic use) Drug Hypersensitivity Female Humans Infant Inflammation (drug therapy) Intraocular Pressure (drug effects) Male Ophthalmic Solutions Ophthalmologic Surgical Procedures Pain Measurement Pain, Postoperative (drug therapy) Propionates (adverse effects, therapeutic use) Prospective Studies Strabismus (surgery)

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