Role of external radiation therapy in urinary cancers.

Abstract

Invasive urinary tumors are relatively rare and their treatment may cause important changes in urinary, sexual, and social functions. A systematic review of external radiation therapy studies in urinary cancers has been carried out. This synthesis of the literature is based on data from meta-analysis, randomized and prospective trials, and retrospective studies. There are few controlled clinical trials using adjuvant or radical radiotherapy +/- chemotherapy in kidney, ureter, and urethra cancers; there are several reports of muscle-invasive bladder cancer using multimodality treatment: intravesical surgery and neo-adjuvant chemotherapy to radiotherapy or concomitant radiochemotherapy with organ preservation. The conclusions reached for renal cancer are controversial; urethra and ureter cancers data are few and inconclusive; sufficient data now exist in literature to demonstrate that conservative management with organ preservation, for muscle-invasive bladder cancer, is a valid alternative to radical cystectomy, viewed as the gold standard.

• Authors: S Parisi, M Troiano, P Corsa, A Raguso, S Cossa, E E Piazzolla, T Munafò, G Sanpaolo, A Natuno, E Maiello
• Journal: Annals of oncology : official journal of the European Society for Medical Oncology (Ann Oncol) Vol. 18 Suppl 6 Pg. vi157-61 (Jun 2007) ISSN: 0923-7534 [Print] England
• PMID: 17591812 (Publication Type: Journal Article, Review, Systematic Review)

Topics

• Humans
• Ureteral Neoplasms (drug therapy, radiotherapy, surgery)
• Urethral Neoplasms (drug therapy, radiotherapy, surgery)
• Urinary Bladder Neoplasms (drug therapy, radiotherapy, surgery)