Treatment response in liver metastases following 90Y SIR-spheres: an evaluation with PET.

Abstract

Selective internal radiation therapy (SIRT) with radiolabeled Yttrium-90 (90Y) microspheres is a relatively new therapeutic option for patients with primary or secondary hepatic malignancy. However, the evaluation of the therapeutic efficacy on anatomic imaging alone is suboptimal. Functional imaging with F18-2-fluoro-2-deoxy-D-glucose (FDG) positron emission tomography (PET) is increasingly utilised in therapy monitoring in malignancy and provides an accurate assessment of metabolic response. We report a case of a 75-year-old gentleman with colorectal hepatic metastases who demonstrated a dramatic metabolic response on PET scan following SIRT. This case illustrates the utility of FDG PET in the assessment of the therapeutic efficacy of 90Y microspheres in colorectal hepatic metastases.

• Authors: Michael Lin, Ivan Ho Shon, Robert Wilson, Scott K D'Amours, Glenn Schlaphoff, Peter Lin
• Journal: Hepato-gastroenterology (Hepatogastroenterology) 2007 Apr-May Vol. 54 Issue 75 Pg. 910-2 ISSN: 0172-6390 [Print] Greece
• PMID: 17591090 (Publication Type: Case Reports, Journal Article)

Chemical References

• Radiopharmaceuticals
• Yttrium Radioisotopes
• Fluorodeoxyglucose F18

Topics

• Aged
• Colorectal Neoplasms (pathology)
• Fluorodeoxyglucose F18
• Humans
• Liver Neoplasms (diagnostic imaging, radiotherapy, secondary)
• Male
• Microspheres
• Positron-Emission Tomography
• Radiopharmaceuticals
• Treatment Outcome
• Yttrium Radioisotopes (administration & dosage, therapeutic use)