Methylenetetrahydrofolate reductase gene polymorphism is not related to the risk of ischemic cerebrovascular disease in a Brazilian population.

Abstract

PURPOSE:

Data are conflicting concerning the risk for ischemic stroke associated with a common polymorphism in the gene encoding 5,10-methylenetetrahydrofolate reductase C677T, which predisposes carriers to hyperhomocysteinemia. A meta-analysis study suggested that the 5,10-methylenetetrahydrofolate reductase 677TT genotype might have a small influence in determining susceptibility to ischemic stroke.

METHODS:

We analyzed the 5,10-methylenetetrahydrofolate reductase 677TT genotype polymorphism in Brazilian subjects with ischemic stroke, using a case-control design.

RESULTS:

We compared 5,10-methylenetetrahydrofolate reductase genotypes in groups of subjects presenting ischemic stroke (n = 127) and normal control (n = 126) and found an odds ratio of 1.97 (95% CI, 0.84-4.64) in a multivariate analysis in which results were adjusted to baseline clinical characteristics of study participants.

CONCLUSION:

We found that the homozygous 5,10-methylenetetrahydrofolate reductase C677T genotype was not a risk factor for ischemic stroke in these Brazilian subjects.

• Authors: Suely Kazue Nagahashi Marie, Samuel Katsuyuki Shinjo, Sueli Mieko Oba-Shinjo, Roseli da Silva, Keila Cardoso Barbosa, Fabio Yamamoto, Milberto Scaff
• Journal: Clinics (Sao Paulo, Brazil) (Clinics (Sao Paulo)) Vol. 62 Issue 3 Pg. 295-300 (Jun 2007) ISSN: 1807-5932 [Print] United States
• PMID: 17589670 (Publication Type: Journal Article)

Chemical References

• Genetic Markers
• Methylenetetrahydrofolate Reductase (NADPH2)

Topics

• Adolescent
• Adult
• Aged
• Aged, 80 and over
• Brain Ischemia (genetics)
• Case-Control Studies
• Female
• Genetic Markers (genetics)
• Genetic Predisposition to Disease (genetics)
• Genotype
• Humans
• Male
• Methylenetetrahydrofolate Reductase (NADPH2) (genetics)
• Middle Aged
• Multivariate Analysis
• Odds Ratio
• Polymorphism, Genetic (genetics)
• Risk Factors