Abstract |
Imiquimod 5% cream has been found to be effective and safe in preventing recurrence of keloids on earlobes after excision. We evaluated the efficacy and safety of imiquimod 5% cream in preventing the recurrence of presternal keloids after excision (3 keloids in 2 patients). After excision with radiofrequency, imiquimod 5% cream was applied once daily at bedtime for 8 weeks, and the defect was left to heal by secondary intention. In all the treated keloids, the defect healed in 6-8 weeks, and no recurrence was seen while on imiquimod application; however, all keloids completely recurred within 4 weeks of stopping imiquimod. Side effects were mild and acceptable in the form of burning and pain. Imiquimod did exert an antifibrotic action but it was short-lived.
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Authors | Amit Kumar Malhotra, Somesh Gupta, Binod K Khaitan, Vinod K Sharma |
Journal | Dermatology (Basel, Switzerland)
(Dermatology)
Vol. 215
Issue 1
Pg. 63-5
( 2007)
ISSN: 1421-9832 [Electronic] Switzerland |
PMID | 17587842
(Publication Type: Case Reports, Journal Article)
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Copyright | 2007 S. Karger AG, Basel |
Chemical References |
- Aminoquinolines
- Ointments
- Imiquimod
|
Topics |
- Administration, Topical
- Adult
- Aminoquinolines
(therapeutic use)
- Combined Modality Therapy
- Dose-Response Relationship, Drug
- Drug Administration Schedule
- Follow-Up Studies
- Humans
- Imiquimod
- Keloid
(drug therapy, prevention & control, surgery)
- Male
- Ointments
- Secondary Prevention
- Severity of Illness Index
- Sternum
- Treatment Outcome
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