Abstract | OBJECTIVE: METHODS: RESULTS: Patients with chronic AOSD quickly responded to anakinra treatment (1 day to 3 days). GC could be tapered. ESR, CRP, WBC, ferritin, and liver enzymes returned to normal. Serum cytokine measurements revealed moderately elevated IL-1beta levels and highly elevated IL-18 levels in active disease, which normalized with anakinra. TNF-alpha and IL-6 were moderately elevated only in the 2 patients with chronic AOSD. In the literature, 17 similar cases have been reported to date. CONCLUSIONS:
Anakinra is effective in treatment-resistant and in life-threatening AOSD. IL-18 serum levels, in addition to CRP, ESR, liver enzymes, ferritin, and WBC, may be helpful in assessing disease activity and response to treatment.
|
Authors | Ina Kötter, Alexander Wacker, Silvia Koch, Jörg Henes, Constanze Richter, Andreas Engel, Ilhan Günaydin, Lothar Kanz |
Journal | Seminars in arthritis and rheumatism
(Semin Arthritis Rheum)
Vol. 37
Issue 3
Pg. 189-97
(Dec 2007)
ISSN: 0049-0172 [Print] United States |
PMID | 17583775
(Publication Type: Case Reports, Journal Article, Review)
|
Chemical References |
- Antirheumatic Agents
- Cytokines
- Interleukin 1 Receptor Antagonist Protein
|
Topics |
- Adult
- Antirheumatic Agents
(therapeutic use)
- Cytokines
(blood)
- Drug Resistance
- Female
- Humans
- Interleukin 1 Receptor Antagonist Protein
(therapeutic use)
- Male
- Still's Disease, Adult-Onset
(blood, drug therapy, immunology)
|