[A comparative study of the efficacy of Vermox, albendazole and medamine in an experimental model of trichocephaliasis in mice].

Abstract

A comparison of the efficacy of albendazole, medamine, and Vermox using an experimental model of Trichocephalus muris in DBA-2 mice showed that Vermox was most effective at all stages of the parasite development. The therapeutic activity of albendazole and medamine depends on daily dose, its dividing through the day and the duration of the treatment. At larval stages of T. muris complete recovery might be achieved using a daily dose of 25 mg/kg for albendazole and 150 mg/kg for medamine, but at the adult stage the doses of the drugs should be 3-4 times higher to achieve 100% effect. The resistance of T. muris to the drugs especially increases at the beginning of egg production.

• Authors: V M Rashid
• Journal: Meditsinskaia parazitologiia i parazitarnye bolezni (Med Parazitol (Mosk)) 1991 Sep-Oct Issue 5 Pg. 44-6 ISSN: 0025-8326 [Print] Russia (Federation)
• Vernacular Title: Sravnitel'noe izuchenie éffektivnosti vermoksa, al'bendazola i medamina na éksperimental'noĭ modeli trikhotsefaleza mysheĭ.
• PMID: 1758364 (Publication Type: Comparative Study, English Abstract, Journal Article)

Chemical References

• Antinematodal Agents
• Benzimidazoles
• Carbamates
• Mebendazole
• Albendazole
• carbendazim

Topics

• Albendazole (administration & dosage, therapeutic use)
• Animals
• Antinematodal Agents (administration & dosage, therapeutic use)
• Benzimidazoles (administration & dosage, therapeutic use)
• Carbamates
• Disease Models, Animal
• Drug Evaluation, Preclinical
• Female
• Male
• Mebendazole (administration & dosage, therapeutic use)
• Mice
• Mice, Inbred DBA
• Time Factors
• Trichuriasis (drug therapy)