Transitional cell carcinoma of the endometrium associated with benign ovarian brenner tumor: a case report with immunohistochemistry molecular analysis and a review of the literature.

Abstract	Transitional cell carcinoma of the endometrium (TCCE) is a subtype of endometrial carcinoma, characterized by a prominent papillary pattern, resembling the papillary carcinoma of the urothelium. This neoplasm is very rare, with only 13 cases reported in the international literature. In this paper, a new case of TCCE associated with benign ovarian Brenner tumor is described. This association is extremely rare, with only 1 other case reported. A review of the literature is performed to delineate the clinico pathologic features of this malignancy. Moreover, immunohistochemical and molecular studies are carried out in the effort to establish the phenotype and etiology of this rare neoplasm. The molecular study, by polymerase chain reaction (PCR) failing to reveal the presence of HPV DNA, demonstrates that neither the TCCE nor the ovarian Brenner tumor is caused by an HPV infection. The association of TCCE with benign ovarian Brenner tumor could be a coincidental event. Conversely, this finding could be the manifestation of a multicentric metaplastic process (neometaplasia), involving both the coelomic epithelium of the ovary and the Mullerian epithelium of the uterus, or the evidence of "field effect" that manifests differently at different anatomical sites. In our view, other cases of TCCE associated with ovarian Brenner tumor should be reported to confirm the last 2 hypotheses.
Authors	Giovanna Giordano, Tiziana D'Adda, Letizia Gnetti, Carla Merisio, Stefano Raboni
Journal	International journal of gynecological pathology : official journal of the International Society of Gynecological Pathologists (Int J Gynecol Pathol) Vol. 26 Issue 3 Pg. 298-304 (Jul 2007) ISSN: 0277-1691 [Print] United States
PMID	17581415 (Publication Type: Case Reports, Journal Article)
Chemical References	DNA, Neoplasm
Topics	Brenner Tumor (complications, genetics, pathology, surgery) Carcinoma, Transitional Cell (complications, genetics, pathology, surgery) DNA, Neoplasm (chemistry, genetics) Endometrial Neoplasms (complications, genetics, pathology, surgery) Female Humans Immunohistochemistry Middle Aged Polymerase Chain Reaction

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