Bupropion and cognitive-behavioral treatment for depression in smoking cessation.

Abstract

This study is a randomized, double-blind, placebo-controlled clinical trial examining the effects of an intensive cognitive-behavioral mood management treatment (CBTD) and of bupropion, both singularly and in combination, on smoking cessation in adult smokers. As an extension of our previous work, we planned to examine the synergistic effects of CBTD and bupropion on smoking cessation outcomes in general and among smokers with depression vulnerability factors. Participants were 524 smokers (47.5% female, M (age) = 44.27 years) who were randomized to one of four 12-week treatments: (a) standard, cognitive-behavioral smoking cessation treatment (ST) plus bupropion (BUP), (b) ST plus placebo (PLAC), (c) standard cessation treatment combined with cognitive-behavioral treatment for depression (CBTD) plus BUP, and (d) CBTD plus PLAC. Follow-up assessments were conducted 2, 6, and 12 months after treatment, and self-reported abstinence was verified biochemically. Consistent with previous studies, bupropion, in comparison with placebo, resulted in better smoking outcomes in both intensive group treatments. Adding CBTD to standard intensive group treatment did not result in improved smoking cessation outcomes. In addition, neither CBTD nor bupropion, either alone or in combination, was differentially effective for smokers with single-past-episode major depressive disorder (MDD), recurrent MDD, or elevated depressive symptoms. However, findings with regard to recurrent MDD and elevated depressive symptoms should be interpreted with caution given the low rate of recurrent MDD and the low level of depressive symptoms in our sample. An a priori test of treatment effects in smokers with these depression vulnerability factors is warranted in future clinical trials.

• Authors: Richard A Brown, Raymond Niaura, Elizabeth E Lloyd-Richardson, David R Strong, Christopher W Kahler, Ana M Abrantes, David Abrams, Ivan W Miller
• Journal: Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco (Nicotine Tob Res) Vol. 9 Issue 7 Pg. 721-30 (Jul 2007) ISSN: 1462-2203 [Print] England
• PMID: 17577801 (Publication Type: Controlled Clinical Trial, Journal Article, Randomized Controlled Trial, Research Support, N.I.H., Extramural)

Chemical References

• Antidepressive Agents, Second-Generation
• Bupropion

Topics

• Adult
• Antidepressive Agents, Second-Generation (therapeutic use)
• Bupropion (therapeutic use)
• Cognitive Behavioral Therapy (methods)
• Combined Modality Therapy
• Comorbidity
• Depression (epidemiology, psychology, therapy)
• Dose-Response Relationship, Drug
• Double-Blind Method
• Female
• Humans
• Male
• Middle Aged
• Psychotherapy, Group
• Smoking (epidemiology, psychology)
• Smoking Cessation (methods)
• Smoking Prevention
• Tobacco Use Disorder (rehabilitation)
• Treatment Outcome