Contact allergy to acrylates/methacrylates in the acrylate and nail acrylics series in southern Sweden: simultaneous positive patch test reaction patterns and possible screening allergens.

Abstract	In a recent study we showed that all our dental personnel/patients were detected with 2-hydroxyethyl methacrylate (2-HEMA) and 2,2-bis[4-(2-hydroxy-3-methacryloxypropoxy)phenyl]propane (bis-GMA). We studied 90 patients tested to the acrylate and nail acrylics series at our department over a 10 year period to see whether screening allergens could be found. Patch testing with an acrylate and nail acrylics series was performed. Among the 10 acrylate/methacrylate-allergic occupational dermatitis patients tested to the acrylate series, the most common allergens were triethyleneglycol diacrylate (TREGDA, 8), diethyleneglycol diacrylate (5), and 1,4-butanediol diacrylate (BUDA, 5). All 10 of these patients would have been picked up by a short screening series combining TREGDA, 2-hydroxypropyl methacrylate (2-HPMA), and BUDA or 1,6-hexanediol diacrylate (HDDA). Among the 14 acrylate/methacrylate-allergic nail patients, the most common allergens were ethylene glycol dimethacrylate (EGDMA, 11), 2-HEMA, (9), and triethyleneglycol dimethacrylate (9). Screening for 3 allergens i.e. 2-HEMA plus EGDMA plus TREGDA, would have detected all 14 nail patients. A short screening series combining 2-HEMA, EGDMA, TREGDA, 2-HPMA, bis-GMA, and BUDA or HDDA would have picked up all our past study patients (dental, industrial, and nail) with suspected allergy to acrylate/methacrylate allergens.
Authors	Anthony Teik-Jin Goon, Magnus Bruze, Erik Zimerson, Chee-Leok Goh, Marléne Isaksson
Journal	Contact dermatitis (Contact Dermatitis) Vol. 57 Issue 1 Pg. 21-7 (Jul 2007) ISSN: 0105-1873 [Print] England
PMID	17577353 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References	Acrylates Allergens
Topics	Acrylates (adverse effects, chemistry) Adult Allergens (adverse effects) Dermatitis, Allergic Contact (diagnosis, etiology) Dermatitis, Occupational (diagnosis, etiology) Female Humans Male Middle Aged Molecular Structure Occupational Exposure (adverse effects) Patch Tests Retrospective Studies Skin (pathology) Sweden

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