Abstract | OBJECTIVE: METHODS: Rat models of HPS were induced by ligating the bile duct to result in the biliary cirrhosis. Thirty male SD rats were randomly divided into three groups with 10 animals in each one: sham operation group (the bile ducts were isolated and 2 ml NS was injected i.p), HPS model group (the bile ducts were ligated and 2 ml NS was injected i.p) and levofloxacin group (the bile ducts were did as the former group and 20 mg/kg ofloxacin injected i.p). After 6 weeks the portal pressure, ratios of dry weight to wet weight of lung (D/W), weight of spleen, plasma levels of endotoxin, MPO active and MDA contents in the lung. Plasma and lavage fluid of lung were examined. The results of the blood-gas analysis, the bacterial culture of blood, bile and ascites and the evaluation of pathologic change of lung be also investigated. RESULTS: In levofloxacin group, portal pressure [(19.28 +/- 2.3) compare with (17.80 +/- 2.18)cm H2O, P<0.01], D/W [(5.1 +/- 0.7) compare with (4.9 +/- 0.7), P <0.01], plasma endotoxin levels [(59 +/- 6.2) compare with (268 +/- 35.6)ng/L, P<0.01], MPO active [(0.40 +/- 0.10) compare with (0.24 +/- 0.03)U, P<0.01] and MDA [(0.32 +/- 0.05) compare with (0.22 +/- 0.03) micromol/L, P<0.01] contents in the lung were significantly decreased compared with those in HPS group, and the inflammation of lung was also obviously alleviated. CONCLUSION: Reduction of endotoxin can attenuate the injury of lung in HPS rats.
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Authors | Wen-bo Wang, Chang-ku Jia, Liang Liang |
Journal | Zhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences
(Zhejiang Da Xue Xue Bao Yi Xue Ban)
Vol. 36
Issue 3
Pg. 285-90
(05 2007)
ISSN: 1008-9292 [Print] China |
PMID | 17571313
(Publication Type: English Abstract, Journal Article)
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Chemical References |
- Anti-Bacterial Agents
- Endotoxins
- Malondialdehyde
- Levofloxacin
- Ofloxacin
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Topics |
- Animals
- Anti-Bacterial Agents
(therapeutic use)
- Bronchoalveolar Lavage Fluid
(chemistry)
- Endotoxins
(blood)
- Hepatopulmonary Syndrome
(blood, drug therapy)
- Levofloxacin
- Lung
(drug effects, metabolism, pathology)
- Male
- Malondialdehyde
(metabolism)
- Ofloxacin
(therapeutic use)
- Portal Pressure
(drug effects)
- Random Allocation
- Rats
- Rats, Sprague-Dawley
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