Pharmacokinetics of florfenicol and its metabolite, florfenicol amine, in dogs.

Abstract

A study on the bioavailability and pharmacokinetics of florfenicol was conducted in six healthy dogs following a single intravenous (i.v.) or oral (p.o.) dose of 20 mg kg(-1) body weight (b.w.). Florfenicol concentrations in serum were determined by a high-performance liquid chromatography/mass spectrometry. Plasma concentration-time data after p.o. or i.v. administration were analyzed by a non-compartmental analysis. Following i.v. injection, the total body clearance was 1.03 (0.49) L kg(-1)h(-1) and the volume of distribution at steady-state was 1.45 (0.82) L kg(-1). Florfenicol was rapidly distributed and eliminated following i.v. injection with 1.11 (0.94)h of the elimination half-life. After oral administration, the calculated mean C(max) values (6.18 microg ml(-1)) were reached at 0.94 h in dogs. The elimination half-life of florfenicol was 1.24 (0.64) h and the absolute bioavailability (F) was achieved 95.43 (11.60)% after oral administration of florfenicol. Florfenicol amine, the major metabolite of florfenicol, was detected in all dogs after i.v. and p.o. administrations.

• Authors: Byung-Kwon Park, Jong-Hwan Lim, Myoung-Seok Kim, Youn-Hwan Hwang, Hyo-In Yun
• Journal: Research in veterinary science (Res Vet Sci) Vol. 84 Issue 1 Pg. 85-9 (Feb 2008) ISSN: 0034-5288 [Print] England
• PMID: 17570454 (Publication Type: Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)

Chemical References

• Anti-Bacterial Agents
• florfenicol amine
• florfenicol
• Thiamphenicol

Topics

• Administration, Oral
• Animals
• Anti-Bacterial Agents (administration & dosage, chemistry, pharmacokinetics)
• Area Under Curve
• Biological Availability
• Cross-Over Studies
• Dogs (metabolism)
• Half-Life
• Injections, Intravenous
• Male
• Molecular Structure
• Thiamphenicol (administration & dosage, analogs & derivatives, chemistry, pharmacokinetics)