[Morphological and proinflammatory expression of the experimental autoimmune prostatitis in the rat model].

Abstract

OBJECTIVE:

To establish a Wistar rat model of chronic abacterial prostatitis (CAP) by injecting purified prostate protein and Freund's complete adjuvant, and to study the influence on the morphology and proinflammatory expression.

METHODS:

Male rats were injected with the Pertussis-Diphteria-Tetanus vaccine into the abdominal cavity and purified prostate protein and Freund's complete adjuvant intradermally at 0 and 30 days. At 60 days, the rats were sacrificed, and then the prostate specimens were observed, under the light microscope and electron microscope, and the changes of proinflammatory expression was observed too, using PCR technique.

RESULTS:

The products of proinflammatory expression, such as eotaxin, iNOS and IL-4 increased markedly. The change of chronic inflammation was shown by light microscope and electron microscope.

CONCLUSION:

Chronic prostatitis is associated with autoimmunity.

• Authors: Lei Chen, Wei-ping Xia, Zhi-heng Zhou
• Journal: Zhonghua nan ke xue = National journal of andrology (Zhonghua Nan Ke Xue) Vol. 13 Issue 5 Pg. 444-8 (May 2007) ISSN: 1009-3591 [Print] China
• PMID: 17569264 (Publication Type: English Abstract, Journal Article)

Chemical References

• Chemotactic Factors, Eosinophil
• Interleukin-4

Topics

• Animals
• Autoimmune Diseases (pathology)
• Chemotactic Factors, Eosinophil (genetics)
• Disease Models, Animal
• Gene Expression
• Interleukin-4 (blood)
• Male
• Polymerase Chain Reaction
• Prostatitis (pathology)
• Random Allocation
• Rats
• Rats, Wistar