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[Evaluation of combination chemotherapy with 5-FU, CDDP and CPT-11 for human gastric carcinoma transplanted into nude mice - comparative study of in vivo chemosensitivity test].

Abstract
We performed in vivo chemosensitivity tests on human gastric carcinoma. To evaluate the efficacy of some combined chemotherapy for human gastric carcinoma maintained in the subcutaneous space in nude mice, we designed the following six experimental groups: 1) 5-FU group, 2) CDDP group, 3) CPT-11 group, 4) combined therapy group of 5-FU and CDDP, 5) combined therapy group of 5-FU and CPT-11, and 6) combined therapy group of CPT-11 and CDDP. An in vivo nude mice assay was performed. Histopathological changes of the tumors in nude mice, treated with anti-cancer agents,were also evaluated and compared to the results of the nude mice assay. Based on histopathological grading,the true positive rate of the nude mice assay was 0%, the true negative rate was 83.3%, and the accuracy rate was 83.3%. CPT-11 appeared to be highly efficacious when given in combination with CDDP in human gastric cancer cell lines. These results suggest that combination chemotherapy with CPT-11 and CDDP is clinically effective for gastric cancer patients.
AuthorsNoriaki Kanamori, Masashi Fujii, Mitsugu Kochi, Teruo Kaiga, Tohru Takahashi, Tadatoshi Takayama
JournalGan to kagaku ryoho. Cancer & chemotherapy (Gan To Kagaku Ryoho) Vol. 34 Issue 6 Pg. 881-4 (Jun 2007) ISSN: 0385-0684 [Print] Japan
PMID17565250 (Publication Type: Comparative Study, English Abstract, Journal Article)
Chemical References
  • irinotecan
  • Cisplatin
  • Fluorouracil
  • Camptothecin
Topics
  • Animals
  • Antineoplastic Combined Chemotherapy Protocols (pharmacology, therapeutic use)
  • Camptothecin (administration & dosage, analogs & derivatives, pharmacology)
  • Cisplatin (administration & dosage, pharmacology)
  • Drug Screening Assays, Antitumor
  • Fluorouracil (administration & dosage, pharmacology)
  • Humans
  • Mice
  • Mice, Nude
  • Neoplasm Transplantation
  • Stomach Neoplasms (drug therapy, pathology)

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