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Cerebral infarction associated with protein C deficiency following allogeneic bone marrow transplantation.

Abstract
Hypercoagulable states associated with deficiencies in circulating anticoagulant protein C occur after chemotherapy for a variety of malignant diseases. Protein C deficiency also occurs following bone marrow transplantation (BMT) and may be responsible for a variety of transplantation-associated complications. We report the case of a child who suffered a stroke associated with low protein C antigen and activity occurring 11 months after allogeneic BMT. Protein C levels recovered spontaneously by 18 months after BMT. We speculate that the protein C deficiency and and resultant hypercoagulable state led to the stroke, and the deficiency of this anticoagulant was a sequela of the transplant.
AuthorsB G Gordon, K L Saving, J A McCallister, P I Warkentin, J R McConnell, W M Roberts, P F Coccia, W D Haire
JournalBone marrow transplantation (Bone Marrow Transplant) Vol. 8 Issue 4 Pg. 323-5 (Oct 1991) ISSN: 0268-3369 [Print] England
PMID1756332 (Publication Type: Case Reports, Journal Article)
Topics
  • Bone Marrow Transplantation (adverse effects)
  • Cerebral Infarction (etiology)
  • Child
  • Female
  • Humans
  • Lymphoma, T-Cell (surgery)
  • Protein C Deficiency
  • Transplantation, Homologous

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