Abstract | OBJECTIVE: This study evaluated the respiratory motion of lungs using a nonlinear motion correction technique for respiratory-gated single photon emission computed tomography (SPECT) images. METHODS: The motion correction technique corrects the respiratory motion of the lungs nonlinearly between two-phase images obtained by respiratory-gated SPECT. The displacement vectors resulting from respiration can be computed at every location of the lungs. Respiratory lung motion analysis is carried out by calculating the mean value of the body axis component of the displacement vector in each of the 12 small regions into which the lungs were divided. In order to enable inter-patient comparison, the 12 mean values were normalized by the length of the lung region along the direction of the body axis. RESULTS: This method was applied to 25 Technetium (Tc)-99m-macroaggregated albumin (MAA) perfusion SPECT images, and motion analysis results were compared with the diagnostic results. It was confirmed that the respiratory lung motion reflects the ventilation function. A statistically significant difference in the amount of the respiratory lung motion was observed between the obstructive pulmonary diseases and other conditions, based on an unpaired Student's t test (P < 0.0001). CONCLUSIONS: A difference in the motion between normal lungs and lungs with a ventilation obstruction was detected by the proposed method. This method is effective for evaluating obstructive pulmonary diseases such as pulmonary emphysema and diffuse panbronchiolitis.
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Authors | Hidenori Ue, Hideaki Haneishi, Hideyuki Iwanaga, Kazuyoshi Suga |
Journal | Annals of nuclear medicine
(Ann Nucl Med)
Vol. 21
Issue 3
Pg. 175-83
(Jun 2007)
ISSN: 0914-7187 [Print] Japan |
PMID | 17561589
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Radiopharmaceuticals
- Technetium Tc 99m Aggregated Albumin
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Topics |
- Artifacts
- Female
- Humans
- Image Enhancement
(methods)
- Image Interpretation, Computer-Assisted
(methods)
- Lung
(diagnostic imaging)
- Male
- Middle Aged
- Movement
- Perfusion
(methods)
- Pulmonary Emphysema
(diagnostic imaging)
- Radiopharmaceuticals
- Reproducibility of Results
- Respiratory Mechanics
- Sensitivity and Specificity
- Technetium Tc 99m Aggregated Albumin
- Tomography, Emission-Computed, Single-Photon
(methods)
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