[Effect of olive antihyperlipidemia capsule on low and high density lipoprotein receptor in rat liver gene expression in hyperlipmia rat liver].

Abstract

OBJECTIVE:

To study on the regulatory mechanism of lipid metabolism disorders in the blood fat of hyperlipemia rat model with Olive Antihyperlipidemia capsule, and do systematic observation on the functions of this medicine on low And high density lipoprotein receptor in rat liver gene expression, and then to clarify the mechanism of action of this medicine on treating hyperlipemia.

METHOD:

To select SD rat as investigated subject. The hyperlipemia rat models were made with feeding high-fat forage and were randomly divided into six groups based on the total cholesterol level at the ratsfasting for 12 hours: group A, B, C, D, E and group F. The samples in the research were collected and analyzed the changes of LDLR/SR-B1 gene expression in rat's liver by RT-PCR.

RESULT:

Olive Antihyperlipidemia capsule can markedly enhance LDLR/SR-B1 gene expression in rat's liver and finally accomplish the purpose of reducing blood fat. The experiment shows this medicine has the remarkable effect on hyperlipidemia and proved the theoretical system of treating hyperlipemia for curing the liver is correct.

CONCLUSION:

Olive Antihyperlipidemia capsule has an applicable value on preventing the cause, enhance LDLR/SR-B1 gene expression in rat's liver and finally accomplish the purpose of reducing blood fat and development of hyperlipemia and its complications.

• Authors: Jin-Sheng Zhang
• Journal: Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica (Zhongguo Zhong Yao Za Zhi) Vol. 32 Issue 6 Pg. 519-22 (Mar 2007) ISSN: 1001-5302 [Print] China
• PMID: 17552160 (Publication Type: English Abstract, Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Capsules
• Drugs, Chinese Herbal
• Hypolipidemic Agents
• Lipoproteins, HDL
• RNA, Messenger
• Receptors, LDL
• Receptors, Lipoprotein
• Scavenger Receptors, Class B
• high density lipoprotein receptors

Topics

• Animals
• Capsules
• Drugs, Chinese Herbal (isolation & purification, pharmacology)
• Gene Expression Regulation (drug effects)
• Hyperlipidemias (genetics, pathology, prevention & control)
• Hypolipidemic Agents (isolation & purification, pharmacology)
• Lipoproteins, HDL (genetics)
• Liver (metabolism)
• Male
• Olea (chemistry)
• Plants, Medicinal (chemistry)
• RNA, Messenger (biosynthesis, genetics)
• Random Allocation
• Rats
• Rats, Sprague-Dawley
• Receptors, LDL (genetics)
• Receptors, Lipoprotein (genetics)
• Scavenger Receptors, Class B (genetics)