Abstract | BACKGROUND: METHODS: We identified 96 patients with severe PGD (P/F < 200) at ICU arrival through a retrospective review of 431 lung transplants performed at our institution from 1992 to 2005. The P/F trend, represented as quartiles of the 12-h percentage change in P/F, was analyzed using multivariate logistic regression. Study outcomes were 90-day death and long-term survival. RESULTS: The median percentage change in P/F over 12 h was + 52% (interquartile range, +20 to 90%). We observed the highest early mortality among those in the lowest quartile of the P/F trend (an increase in P/F <or= 20%). Ninety-day death rates decreased across the quartiles (low quartile, 32%; low-mid quartile, 9%; high-mid quartile, 5%; high quartile, 5%; test for trend, p = 0.007). After adjustment for the use of cardiopulmonary bypass, those in the lowest quartile of P/F trend had 6.8 times the odds of early death vs patients with a more favorable trend (odds ratio, 6.80; 95% confidence interval, 1.73 to 0.51; p = 0.007). In the first 5 years after transplant, there were significantly more deaths within the low quartile group vs those with a more rapidly increasing P/F trend (log-rank test, p = 0.01). CONCLUSIONS: Among lung recipients with severe PGD at ICU arrival, an improvement in P/F <or= 20% in the first 12 h portends a poor outcome.
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Authors | Matthew E Prekker, Cynthia S Herrington, Marshall I Hertz, David M Radosevich, Peter S Dahlberg |
Journal | Chest
(Chest)
Vol. 132
Issue 3
Pg. 991-7
(Sep 2007)
ISSN: 0012-3692 [Print] United States |
PMID | 17550938
(Publication Type: Journal Article)
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Topics |
- Adult
- Blood Gas Analysis
- Female
- Graft Survival
(physiology)
- Humans
- Lung Diseases
(blood, physiopathology, surgery)
- Lung Transplantation
(mortality)
- Male
- Middle Aged
- Predictive Value of Tests
- Retrospective Studies
- Severity of Illness Index
- Survival Rate
- Time Factors
- Treatment Outcome
- Ventilation-Perfusion Ratio
(physiology)
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