Pharmacokinetics of once-daily tenofovir, emtricitabine, ritonavir and fosamprenavir in HIV-infected subjects.

Abstract

HAART has decreased the incidence of AIDS and death among HIV-infected individuals dramatically. This approach often becomes cumbersome to patients, involving multiple drugs administered on varying schedules. We investigated the pharmacokinetics, efficacy, and tolerability of a once-daily regimen of fosamprenavir, tenofovir, emtricitabine and ritonavir in HIV-infected treatment-naive subjects. No clinically significant interaction between the drugs was noted, and the regimen showed good efficacy and tolerability over the course of 48 weeks.

• Authors: David A Parks, Harold C Jennings, Christopher W Taylor, Edward P Acosta
• Journal: AIDS (London, England) (AIDS) Vol. 21 Issue 10 Pg. 1373-5 (Jun 19 2007) ISSN: 0269-9370 [Print] England
• PMID: 17545719 (Publication Type: Journal Article)

Chemical References

• Antiviral Agents
• Carbamates
• Furans
• HIV Protease Inhibitors
• Organophosphates
• Organophosphonates
• RNA, Viral
• Reverse Transcriptase Inhibitors
• Sulfonamides
• Deoxycytidine
• Tenofovir
• Emtricitabine
• Adenine
• Ritonavir
• fosamprenavir

Topics

• Adenine (administration & dosage, analogs & derivatives, blood, pharmacokinetics)
• Adolescent
• Adult
• Antiviral Agents (administration & dosage, blood, pharmacokinetics)
• Carbamates (administration & dosage, blood, pharmacokinetics)
• Deoxycytidine (administration & dosage, analogs & derivatives, blood, pharmacokinetics)
• Drug Administration Schedule
• Drug Therapy, Combination
• Emtricitabine
• Furans
• HIV Infections (blood, drug therapy)
• HIV Protease Inhibitors (administration & dosage, blood, pharmacokinetics)
• Humans
• Organophosphates (administration & dosage, blood, pharmacokinetics)
• Organophosphonates (administration & dosage, blood, pharmacokinetics)
• RNA, Viral (analysis)
• Reverse Transcriptase Inhibitors (administration & dosage, blood, pharmacokinetics)
• Ritonavir (administration & dosage, blood, pharmacokinetics)
• Sulfonamides (administration & dosage, blood, pharmacokinetics)
• Tenofovir
• Treatment Outcome