[Correlation between MHC class I-related chain A gene *008 allele and human cytomegalovirus infection].

Abstract

OBJECTIVE:

To investigate the correlation between MHC class I-related chain A (MICA) gene *008 allele and human cytomegalovirus (HCMV) infection.

METHODS:

MICA*008 allele was detected in 86 patients with chronic granulocytic leukemia and 81 unrelated normal individuals by way of sequence-specific primers (PCR-SSP). Anti-HCMV IgM was also detected in the sera of these subjects with enzyme linked immunosorbent assay (ELISA).

RESULTS:

MICA*008 allele frequency was lower in patients with chronic granulocytic leukemia than in the control group (22.2% vs 34.3%, Chi(2)=4.98, P<0.05). The infection rate of HCMV was significantly higher in those individuals with genotype of MICA*008 (-) than in those with MICA*008 (+), and moderate correlation was suggested between MICA*008 and HCMV infection (C=0.5829, 0.6142).

CONCLUSION:

Individuals with MICA*008 positivity is not liable to HCMV infection, but those with MICA*008 (-) can be vulnerable to HCMV infection, suggesting an inverse correlation between MICA*008 allele with HCMV.

• Authors: Bai-sheng Huang, Qi-zhi Luo, Bing Mei, Ping Yu
• Journal: Nan fang yi ke da xue xue bao = Journal of Southern Medical University (Nan Fang Yi Ke Da Xue Xue Bao) Vol. 27 Issue 4 Pg. 509-11 (Apr 2007) ISSN: 1673-4254 [Print] China
• PMID: 17545046 (Publication Type: English Abstract, Journal Article)

Chemical References

• Histocompatibility Antigens Class I
• MHC class I-related chain A

Topics

• Alleles
• Cytomegalovirus Infections (genetics)
• Gene Frequency
• Genetic Predisposition to Disease
• Genotype
• Histocompatibility Antigens Class I (genetics)
• Humans
• Leukemia, Myelogenous, Chronic, BCR-ABL Positive (genetics, virology)