Synthesis, spectroscopic and X-ray characterization of a copper(II) complex with the Schiff base derived from pyridoxal and aminoguanidine: NMR spectral studies of the ligand.

Abstract

A copper(II) complex with the pyridoxal-aminoguanidine (PL-AG) Schiff base adduct, as an organic compound of the very potent biological activity and promising pharmacological importance in the treatment of diabetic complications, has been prepared and characterized. The X-ray structural analysis of the [CuCl2(PL-AG)] complex showed that it has a distorted pseudo-square-pyramidal (4+1) structure with the tridentate ONN Schiff base in the equatorial plane, with the Cu-O(1), Cu-N(1) and Cu-N(3) bond lengths of 1.917(2)A, 1.930(2)A and 1.984(2)A, respectively. The bond length of the equatorial Cu-Cl(1) is 2.279(1)A, while that of the apical Cu-Cl(2) is 2.792(1)A. Pyridoxal fragment is coordinated in its zwitterionic form. In addition to the X-ray structural analysis, the complex was characterized by IR spectrometric, conductometric and magnetic techniques, and the ligand itself by IR, 1H and 13C NMR spectra.

• Authors: Vukadin M Leovac, Milan D Joksović, Vladimir Divjaković, Ljiljana S Jovanović, Zana Saranović, Andrej Pevec
• Journal: Journal of inorganic biochemistry (J Inorg Biochem) Vol. 101 Issue 7 Pg. 1094-7 (Jul 2007) ISSN: 0162-0134 [Print] United States
• PMID: 17544151 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Guanidines
• Ligands
• Schiff Bases
• Pyridoxal
• Copper
• pimagedine

Topics

• Copper (chemistry)
• Crystallography, X-Ray (methods)
• Guanidines (chemistry)
• Ligands
• Magnetic Resonance Spectroscopy (methods)
• Models, Molecular
• Molecular Structure
• Pyridoxal (chemistry)
• Schiff Bases (chemistry)