Dose-response effects of different plant sterol sources in fat spreads on serum lipids and C-reactive protein and on the kinetic behavior of serum plant sterols.

To test the dose-response effect on low-density lipoprotein cholesterol (LDL-c) of plant sterols (PS) from different sources in a low-fat spread.
Dose responses of soybean oil (BO), tall oil (TO) and a mix of tall oil and rapeseed oil (TO/RP) as fatty acid esters were tested in a parallel design in free-living subjects recruited from the general community who had elevated cholesterol concentrations. Subjects received either control for 6 weeks or 1.6 g PS per day for 3 weeks, then 3.0 g/day for 3 weeks.
LDL-c was lowered significantly by consumption of 1.6 g/day of PS (-10.4%, range -7.3 to -11.4%). Increasing the dose to 3.0 g/day modestly reduced LDL-c concentrations further to -14.7%. TO, containing 78% sitosterol, produced an increase in serum sitosterol of 6.5 nmol/ml, while BO, containing only 27% campesterol, produced an increase in serum campesterol of 9.5 nmol/ml in 6 weeks. After PS withdrawal, serum sterols declined by 50% within 2 weeks.
Different PS sources were equally effective in lowering serum LDL-c concentrations. The decrease in absolute concentrations of LDL-c was dependent on the baseline concentrations.
AuthorsP M Clifton, M Mano, G S M J E Duchateau, H C M van der Knaap, E A Trautwein
JournalEuropean journal of clinical nutrition (Eur J Clin Nutr) Vol. 62 Issue 8 Pg. 968-77 (Aug 2008) ISSN: 0954-3007 [Print] England
PMID17538539 (Publication Type: Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)
Chemical References
  • Cholesterol, HDL
  • Cholesterol, LDL
  • Phytosterols
  • Sitosterols
  • Triglycerides
  • Margarine
  • C-Reactive Protein
  • Cholesterol
  • Adult
  • Aged
  • C-Reactive Protein (analysis)
  • Cholesterol (analogs & derivatives, blood)
  • Cholesterol, HDL (blood, drug effects)
  • Cholesterol, LDL (blood, drug effects)
  • Cross-Over Studies
  • Dose-Response Relationship, Drug
  • Double-Blind Method
  • Female
  • Food, Fortified
  • Humans
  • Hypercholesterolemia (blood, therapy)
  • Male
  • Margarine
  • Middle Aged
  • Phytosterols (analysis, pharmacology)
  • Sitosterols (analysis, pharmacology)
  • Triglycerides (blood)
  • Young Adult

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!

Choose Username:
Verify Password:
Enter Code Shown: