Efficacy of mitomycin-C irrigation after balloon dacryocystoplasty.

Abstract

PURPOSE:

To evaluate the safety and efficacy of mitomycin-C irrigation after balloon dacryocystoplasty in the treatment of epiphora caused by obstruction of the lacrimal system.

MATERIALS AND METHODS:

Thirty-five lacrimal systems in 33 patients with obstruction of the lacrimal system were assigned to one of two groups: 17 lacrimal systems were irrigated with mitomycin-C after balloon dacryocystoplasty (mytomycin-C group), and 18 were not irrigated with mitomycin-C after balloon dacryocystoplasty (non-mitomycin-C group). In the mitomycin-C group, the lacrimal systems were irrigated with 0.2 mg/mL mitomycin-C via the inferior lacrimal punctum in three different sessions: immediately, 1 week, and 1 month after balloon dacryocystoplasty. The cumulative patency rates after balloon dacryocystoplasty were calculated by using the Kaplan-Meier method and were compared between the two groups with use of the log-rank test.

RESULTS:

Balloon dacryocystoplasty and subsequent mitomycin-C irrigation were technically successful in all lacrimal systems. There were no side effects or complications associated with mitomycin-C use. The cumulative patency rate in the mitomycin-C group was significantly higher than that in the non-mitomycin-C group after balloon dacryocystoplasty (P = .0150, log-rank test).

CONCLUSIONS:

Mitomycin-C irrigation is safe and effective in increasing the patency rate of the lacrimal system after balloon dacryocystoplasty.

• Authors: Kyung Rae Kim, Ho-Young Song, Ji Hoon Shin, Jin Hyoung Kim, Eugene K Choi, Zheng-Qiang Yang, Yong Jae Lee
• Journal: Journal of vascular and interventional radiology : JVIR (J Vasc Interv Radiol) Vol. 18 Issue 6 Pg. 757-62 (Jun 2007) ISSN: 1051-0443 [Print] United States
• PMID: 17538138 (Publication Type: Comparative Study, Journal Article)

Chemical References

• Mitomycin

Topics

• Adult
• Aged
• Aged, 80 and over
• Catheterization
• Female
• Follow-Up Studies
• Humans
• Kaplan-Meier Estimate
• Lacrimal Apparatus Diseases (diagnostic imaging, drug therapy, etiology, physiopathology, therapy)
• Lacrimal Duct Obstruction (complications, diagnostic imaging, drug therapy, therapy)
• Male
• Middle Aged
• Mitomycin (therapeutic use)
• Radiography
• Retrospective Studies
• Therapeutic Irrigation (methods)
• Time Factors
• Treatment Outcome