Abstract |
We report an autopsy case of paraneoplastic opsoclonus-myoclonus-ataxia syndrome associated with small cell carcinoma of the lung. Chemotherapy and lung lobectomy resulted in complete tumor remission and disappearance of myoclonus. However, emotional and behavioral disturbances relapsed and remitted associated with exacerbation of truncal ataxia and ocular flutter, which responded favorably to prednisolone. At autopsy, after 2 years and 11 months of illness, there was no recurrence of cancer. Neuropathologically, only the cerebellum was affected, with diffuse loss of Purkinje cells and dentate neurons, suggesting that the paraneoplastic cerebellar involvement may be responsible for the cognitive affective symptoms in our patient.
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Authors | Shinji Ohara, Naoko Iijima, Kensuke Hayashida, Takashi Oide, Satoshi Katai |
Journal | Movement disorders : official journal of the Movement Disorder Society
(Mov Disord)
Vol. 22
Issue 9
Pg. 1320-4
(Jul 15 2007)
ISSN: 1531-8257 [Electronic] United States |
PMID | 17534981
(Publication Type: Case Reports, Journal Article)
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Copyright | 2007 Movement Disorder Society |
Topics |
- Autopsy
(methods)
- Carcinoma, Small Cell
(complications, pathology, therapy)
- Cerebellar Diseases
(complications, pathology, therapy)
- Cognition Disorders
(complications, pathology, therapy)
- Humans
- Lung Neoplasms
(complications, pathology, therapy)
- Male
- Middle Aged
- Paraneoplastic Syndromes
(complications, pathology, therapy)
- Retrospective Studies
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