Abstract | BACKGROUND: Cession of heroin use may be followed by a protracted-abstinence (PA) syndrome consisting of craving, negative mood, and physiological changes. PA symptoms have rarely been compared between drug-free and methadone-maintained former heroin users after similar lengths of heroin abstinence. METHODS: Seventy former heroin users were included in one of four groups: in day 15-45 of methadone maintenance therapy (short-term MMT), in month 5-6 of MMT (long-term MMT), opiate-free for 15-45 days after methadone-assisted heroin detoxification (short-term post- methadone), and opiate-free for 5-6 months after methadone-assisted heroin detoxification (long-term post- methadone). PA symptoms (negative mood, dyssomnia, somatization, and craving), and blood pressure and pulse were assessed pre- and post-neutral videotape and pre- and post- heroin videotape. RESULTS:
Dyssomnia and the total PA score were worst in short-term post- methadone participants, mood was best in long-term MMT participants, and cue-induced craving was least severe in long-term MMT participants. Blood pressure and pulse did not differ across groups. CONCLUSIONS: Even after acute withdrawal, the first months of heroin abstinence after methadone-assisted detoxification may be more difficult in terms of cue-induced craving and other PA symptoms than the first months of heroin abstinence during MMT. Our findings add to the literature supporting MMT for prevention of cue-induced heroin craving.
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Authors | Jie Shi, Li-Yan Zhao, David H Epstein, Xiao-Li Zhang, Lin Lu |
Journal | Pharmacology, biochemistry, and behavior
(Pharmacol Biochem Behav)
Vol. 87
Issue 1
Pg. 141-5
(May 2007)
ISSN: 0091-3057 [Print] United States |
PMID | 17532034
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
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Topics |
- Adult
- Blood Pressure
(drug effects)
- China
- Cues
- Heart Rate
(drug effects)
- Heroin Dependence
(psychology, rehabilitation)
- Humans
- Male
- Methadone
(therapeutic use)
- Mood Disorders
(etiology, psychology)
- Narcotics
(therapeutic use)
- Photic Stimulation
- Sleep Wake Disorders
(etiology, psychology)
- Somatoform Disorders
(etiology, psychology)
- Substance Withdrawal Syndrome
(psychology)
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