Abstract | OBJECTIVE: To study the relationship between TCM syndrome type and HBV- DNA in serum and peripheral blood mononuclear cells (PBMCs) in chronic hepatitis B (CHB) patients. METHODS: The serum HBV markers,HBV- DNA levels in serum and PBMCs, were quantitatively detected in 220 CHB patients by PCR method, and TCM syndrome type of 205 patients were differentiated. RESULTS: Arranged from low to high, the percentages of CHB patients with the serum HBV- DNA > or = 1.0 x l0(5) copy/mL (high viral loading) in the five syndrome types were as follows: damp-heat retention in middle-jiao syndrome (DHRS, 55.2%), blood stasis blocking collateral syndrome (BSBC), Gan-Shen yin deficiency syndrome (GSYS), Pi-Shen yang deficiency syndrome (PSDS) and Gan stagnation with Pi deficiency syndrome (GSPS, 82.5%), the difference was significant between DHRS and GSPS; those with HBV- DNA in PBMCs infection were: GSYS (27.3%), DHRS (34.3%), BSBC (53.1%) and GSPS (77.2%). The percentage in GSPS was the highest, which was significantly different to that in other syndromes. CONCLUSION: Amount of serum HBV- DNA and PBMCs HBV- DNA infection has certain correlation with the TCM syndrome type of CHB. The highest percentage of patients with HBV- DNA > or = 1.0 x l0(5) copy/mL and PBMCs HBV- DNA infection presented in CHB patients of GSPS type. We should pay more attention to strengthen genuine qi to eliminate pathogenic factors in treatment of CHB.
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Authors | Yu-qiang Mi, Shu-wen Zheng, Hong Zhang |
Journal | Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine
(Zhongguo Zhong Xi Yi Jie He Za Zhi)
Vol. 27
Issue 4
Pg. 296-9
(Apr 2007)
ISSN: 1003-5370 [Print] China |
PMID | 17526164
(Publication Type: English Abstract, Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
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Topics |
- Adolescent
- Adult
- Aged
- DNA, Viral
(blood)
- Diagnosis, Differential
- Female
- Hepatitis B virus
(genetics)
- Hepatitis B, Chronic
(pathology, therapy, virology)
- Humans
- Leukocytes, Mononuclear
(virology)
- Male
- Medicine, Chinese Traditional
- Middle Aged
- Syndrome
- Young Adult
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