Clinical study of uric acid urolithiasis.

Abstract

Uric acid urolithiasis develops from various causes. To investigate the clinical and biochemical presentation of patients with uric acid urolithiasis, a retrospective study was designed. A total of 46 cases were enrolled between January 2004 and December 2005. The compositions of the stones were analyzed by infrared spectrophotometry. There were 39 males (84.8%) and seven females (15.2%), with a mean age of 61.5 +/- 10.6 years and mean body mass index (BMI) of 26.7 +/- 3.1 kg/m2. The stone location was kidney in 10 (21.7%), ureter in 22 (41.8%), and bladder in 14 (30.5%). Multiple stones were diagnosed in 36 patients (78.3%). Pre-existing comorbidities included diabetes mellitus in 11 patients (23.9%), hypertension in 23 (50%), gout in 13 (28.2%), and benign prostatic hyperplasia in 14 (30.4%). Mean serum creatinine and uric acid was 1.6 +/- 0.6 mg/dL and 7.6 +/- 1.8 mg/dL, respectively. There were 27 patients (58%) with creatinine > 1.4 mg/dL. The mean urinary pH was 5.42 +/- 0.46. Patients with uric acid urolithiasis were predominantly male, older, with higher BMI, multiple stone presentation, with lower urinary pH, and hyperuricemia. Exacerbation of the renal function should also be of concern because of the high proportion of patients with renal insufficiency diagnosed in this study.

• Authors: Yii-Her Chou, Wei-Ming Li, Ching-Chia Li, Shu-Pin Huang, Chia-Chu Liu, Wen-Jeng Wu, Hsi-Lin Hsiao, Tu-Hao Chang, Yung-Shun Juan, Chien-Yu Su, Hsing Hsu, Chun-Hsiung Huang
• Journal: The Kaohsiung journal of medical sciences (Kaohsiung J Med Sci) Vol. 23 Issue 6 Pg. 298-301 (Jun 2007) ISSN: 1607-551X [Print] China (Republic : 1949- )
• PMID: 17525014 (Publication Type: Journal Article)

Chemical References

• Uric Acid

Topics

• Adult
• Aged
• Body Mass Index
• Female
• Humans
• Male
• Middle Aged
• Sex Factors
• Uric Acid (metabolism)
• Urolithiasis (etiology)