Abstract | BACKGROUND:
Melasma is a common acquired hypermelanosis that is difficult to treat. Several chemical peeling agents were used in treatment of melasma. Topical vitamin C was also used with minimal side effects. AIM: PATIENTS AND METHODS: Thirty women with bilateral epidermal melasma (Fitzpatrick skin types III and IV) were divided into two groups (A and B, 15 patients each). Before therapy, digital photography and a melasma area and severity index (MASI) score were done for each patient. Groups A and B were primed for 2 weeks before TCA peel. Group B also applied 5% ascorbic acid topically once daily; 20% TCA peel was done for all patients weekly until clearance of melasma or for a maximum of six peels. Group B continued to use 5% ascorbic acid topically in between peels and during the 16-week follow-up period. Patients were assessed at the end of peeling sessions and at the end of follow-up by photography, MASI score, and a global evaluation by the patient. RESULTS: Group B compared with group A showed a significant decrease in MASI score at the end of TCA peels (P < 0.001) and at the end of the 16-week follow-up period (P < 0.003). Global evaluation showed that 13 patients (87%) in group B improved or maintained their improvement compared with only 10 patients (67%) in group A. CONCLUSION:
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Authors | Mohsen Mohamed Soliman, Shahira Abdel-Rahman Ramadan, Dalia Ahmed Bassiouny, Marwa Abdelmalek |
Journal | Journal of cosmetic dermatology
(J Cosmet Dermatol)
Vol. 6
Issue 2
Pg. 89-94
(Jun 2007)
ISSN: 1473-2165 [Electronic] England |
PMID | 17524124
(Publication Type: Clinical Trial, Comparative Study, Journal Article)
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Chemical References |
- Dermatologic Agents
- Tretinoin
- Trichloroacetic Acid
- Ascorbic Acid
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Topics |
- Administration, Cutaneous
- Adult
- Ascorbic Acid
(administration & dosage, adverse effects)
- Chemexfoliation
(adverse effects, methods)
- Dermatologic Agents
(administration & dosage, adverse effects)
- Drug Administration Schedule
- Drug Therapy, Combination
- Facial Dermatoses
(therapy)
- Female
- Humans
- Melanosis
(therapy)
- Middle Aged
- Severity of Illness Index
- Treatment Outcome
- Tretinoin
(administration & dosage)
- Trichloroacetic Acid
(administration & dosage, adverse effects)
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