HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

[Paclitaxel-induced lupus].

AbstractINTRODUCTION:
Paclitaxel (Taxol) is a drug derived from the bark of the Pacific yew tree and is widely used in cancer treatment, especially for breast, ovarian, and lung cancers. It has not previously been reported to induce lupus.
CASE:
We report the case of a woman with ovarian cancer who developed paclitaxel-induced lupus on two occasions. Both times, the paclitaxel dramatically improved the ovarian cancer.
DISCUSSION:
The diagnosis of lupus was confirmed by the initial skin appearance, elevated levels of antinuclear antibodies, recurrence on reintroduction, and biopsy results. To our knowledge, it is the first case reported of paclitaxel-induced lupus.
AuthorsAlain Lortholary, Myriam Cary-Ten Have Dallinga, Claude El Kouri, Nadine Morineau, Jean-François Ramée
JournalPresse medicale (Paris, France : 1983) (Presse Med) Vol. 36 Issue 9 Pt 1 Pg. 1207-8 (Sep 2007) ISSN: 0755-4982 [Print] France
Vernacular TitleLupus induit par le paclitaxel.
PMID17521858 (Publication Type: Case Reports, English Abstract, Journal Article)
Chemical References
  • Anti-Inflammatory Agents
  • Antibodies, Antinuclear
  • Antineoplastic Agents, Phytogenic
  • Recombinant Proteins
  • epoetin beta
  • Erythropoietin
  • betamethasone-17,21-dipropionate
  • Betamethasone
  • Paclitaxel
Topics
  • Aged
  • Anti-Inflammatory Agents (administration & dosage, therapeutic use)
  • Antibodies, Antinuclear (analysis)
  • Antineoplastic Agents, Phytogenic (adverse effects, therapeutic use)
  • Betamethasone (administration & dosage, analogs & derivatives, therapeutic use)
  • Biopsy
  • Drug Therapy, Combination
  • Erythropoietin (administration & dosage, therapeutic use)
  • Female
  • Humans
  • Lupus Erythematosus, Cutaneous (chemically induced, diagnosis, drug therapy, immunology, pathology)
  • Ovarian Neoplasms (drug therapy)
  • Paclitaxel (adverse effects)
  • Recombinant Proteins
  • Recurrence
  • Skin (pathology)
  • Treatment Outcome

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: