Topical tacrolimus for the treatment of lichen simplex chronicus.

Abstract

Owing to severe itching and scratching, the natural course of lichen simplex chronicus (LSC) is clinically characterized by typical lichenoid lesions. Topical corticosteroids are often used to treat LSC but after withdrawal a relapse will sometimes occur. Therefore, LSC can be difficult to treat over time. We report a 13-year-old boy suffering from LSC on two symmetrical circumscribed areas on the temple, whose lesions healed completely with tacrolimus 0.1% ointment within approximately 9 months. During active treatment no adverse drug reaction was observed. The patient is completely free of symptoms 3 years after cessation of treatment. We conclude that topical tacrolimus can be used as an effective, long-lasting therapeutic modality in treating LSC, especially in sensitive skin areas such as the face.

• Authors: Roland Aschoff, Gottfried Wozel
• Journal: The Journal of dermatological treatment (J Dermatolog Treat) Vol. 18 Issue 2 Pg. 115-7 ( 2007) ISSN: 0954-6634 [Print] England
• PMID: 17520470 (Publication Type: Case Reports, Journal Article)

Chemical References

• Immunosuppressive Agents
• Tacrolimus

Topics

• Administration, Cutaneous
• Adolescent
• Diagnosis, Differential
• Facial Dermatoses (diagnosis, drug therapy, pathology)
• Humans
• Immunosuppressive Agents (administration & dosage, therapeutic use)
• Male
• Neurodermatitis (diagnosis, drug therapy, pathology)
• Tacrolimus (administration & dosage, therapeutic use)