Abstract | OBJECTIVE: STUDY DESIGN: A short-term double-blind cross-over pilot study comparing uncooked physically modified cornstarch (WMHM20) with uncooked cornstarch in patients with GSD types Ia, Ib and III. Twenty-one patients (ages 3-47, 9 female) were given 2 g/kg cornstarch or WMHM20 mixed in water. Blood glucose, lactate and insulin, and breath hydrogen and (13)CO2 enrichment were measured, at baseline and after each load. The hourly biochemical evaluations terminated when blood glucose was < or = 3.0 mmol/L, when the study period had lasted 10 h or when the patient wished to end the test. The alternative starch was administered under similar trial conditions a median of 10 days later. RESULTS: CONCLUSION: These data indicate longer duration of euglycaemia and better short-term metabolic control in the majority of GSD patients with WMHM20 compared to cornstarch.
|
Authors | K Bhattacharya, R C Orton, X Qi, H Mundy, D W Morley, M P Champion, S Eaton, R F Tester, P J Lee |
Journal | Journal of inherited metabolic disease
(J Inherit Metab Dis)
Vol. 30
Issue 3
Pg. 350-7
(Jun 2007)
ISSN: 1573-2665 [Electronic] United States |
PMID | 17514432
(Publication Type: Controlled Clinical Trial, Journal Article, Research Support, Non-U.S. Gov't)
|
Chemical References |
|
Topics |
- Double-Blind Method
- Female
- Glycogen Storage Disease
(diet therapy, metabolism)
- Glycolysis
- Humans
- Male
- Starch
|