[Ketoprofen in the prevention of postoperative pain in abdominal surgery. A multicenter study].

Abstract

Two-hundred-forty-eight patients undergoing abdominal surgery were admitted to a multicentric clinical trial. The patients were randomly assigned to a single i.v. dose of ketoprofen or acetylsalicylic acid, 15 minutes after the end of operation. Ketoprofen showed a better analgesic activity with a statistically significant difference at 2 and 4 hours after administration. Two patients treated with ketoprofen reported vomiting and skin rash respectively. The results of this study confirm the efficacy of ketoprofen for the prophylaxis of postoperative pain in abdominal surgery.

• Authors: G Avila, G Balbo, R Biasiato, F M Brighenti, R Conte, I Donini, E Landi, G Marzocca, U Mazzi, F Morino
• Journal: Il Giornale di chirurgia (G Chir) 1991 Aug-Sep Vol. 12 Issue 8-9 Pg. 456-8 ISSN: 0391-9005 [Print] Italy
• Vernacular Title: Il ketoprofene nella profilassi del dolore postoperatorio in chirurgia addominale. Studio multicentrico.
• PMID: 1751342 (Publication Type: Clinical Trial, Comparative Study, Journal Article, Multicenter Study, Randomized Controlled Trial)

Chemical References

• Analgesics
• Ketoprofen
• Lysine
• Aspirin
• acetylsalicylic acid lysinate

Topics

• Abdomen (surgery)
• Adolescent
• Adult
• Aged
• Aged, 80 and over
• Analgesics (therapeutic use)
• Aspirin (analogs & derivatives, therapeutic use)
• Drug Tolerance
• Female
• Humans
• Ketoprofen (therapeutic use)
• Lysine (analogs & derivatives, therapeutic use)
• Male
• Middle Aged
• Pain, Postoperative (prevention & control)