Abstract | OBJECTIVES: METHODS: The clinical records of all patients with recurrent gynecological cancer and CKD at the University of Texas M.D. Anderson Cancer Center from 08/1999 to 08/2006 were reviewed retrospectively to identify patients who received PLD. RESULTS: Twenty-eight patients were identified, which included 14 with epithelial ovarian cancer, 4 with peritoneal cancer, and 10 with other gynecologic cancers. CKD was defined as a creatinine clearance (CrCl) of <90 ml/min/1.73 m(2) and classified as mild (5 patients), moderate (16 patients), or severe (7 patients) (CrCl 60-89, 30-59, and <30 ml/min/1.73 m(2), respectively). The initial doses of PLD were classified into regular initial dose (40 mg/m(2)/4 weeks) and lower initial dose (30-35 mg/m(2)/4 weeks). The median cycle was 4.5 (range 1-17). The incidence of grade 3-4 palmar-plantar erythrodysesthesia, stomatitis, and hematologic toxicity was 11.1% (2/18), 5.6% (1/18), and 16.7% (3/18) among 18 patients with an initial dose of 40 mg/m(2)/4 weeks, which included 5, 10, and 3 patients with mild, moderate, and severe CKD, respectively. Dose reduction due to toxicities occurred in 33.3% (6/18) patients. In 18 patients with ovarian and peritoneal cancer (all platinum-resistant), the rates of complete response, partial response, stable disease, and progression were 0%, 11.1%, 44.4%, and 44.4%, respectively. CONCLUSIONS: Patients with CKD who received PLD therapy at an initial dose of 40 mg/m(2)/4 weeks may require greater subsequent dose reduction mainly secondary to mucocutaneous and hematologic toxicities. Treatment response in this population with ovarian and peritoneal cancer was similar to that of patients with normal renal function.
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Authors | Yanfang Li, Kevin W Finkel, Wei Hu, Siqing Fu, Jihong Liu, Robert Coleman, John J Kavanagh |
Journal | Gynecologic oncology
(Gynecol Oncol)
Vol. 106
Issue 2
Pg. 375-80
(Aug 2007)
ISSN: 0090-8258 [Print] United States |
PMID | 17512575
(Publication Type: Journal Article)
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Chemical References |
- Antibiotics, Antineoplastic
- liposomal doxorubicin
- Polyethylene Glycols
- Doxorubicin
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Topics |
- Adult
- Aged
- Aged, 80 and over
- Antibiotics, Antineoplastic
(adverse effects, therapeutic use)
- Doxorubicin
(adverse effects, analogs & derivatives, therapeutic use)
- Female
- Genital Neoplasms, Female
(complications, drug therapy)
- Humans
- Kidney Failure, Chronic
(complications)
- Middle Aged
- Polyethylene Glycols
(adverse effects, therapeutic use)
- Retrospective Studies
- Treatment Outcome
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