Abstract | OBJECTIVE: Some patients with symptomatic non-gonococcal urethritis (NGU) are negative for Chlamydia trachomatis, mycoplasmas and ureaplasmas. The optimal antimicrobial chemotherapy for such NGU has not fully been elucidated, though many studies of antimicrobial chemotherapies for C. trachomatis-positive NGU have been performed. We assessed the efficacy of antimicrobial agents that are active against C. trachomatis on non-mycoplasmal, non-ureaplasmal and non-chlamydial NGU (NMNUNCNGU). METHODS: One hundred men whose first-pass urine samples were negative for C. trachomatis, Mycoplasma genitalium, Mycoplasma hominis, Ureaplasma parvum, and Ureaplasma urealyticum were treated with levofloxacin, gatifloxacin, minocycline, or clarithromycin for 7 days. Urethritis symptoms and the presence of polymorphonuclear leukocytes (PMNL) in urethral smears were assessed before and after treatment. RESULTS: CONCLUSION: Our present findings suggest that antimicrobial agents active against C. trachomatis are effective against NMNUNCNGU and that a 7-day treatment regimen with an appropriate antimicrobial agent may be sufficient to manage patients with NMNUNCNGU.
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Authors | Shin-Ichi Maeda, Masayoshi Tamaki, Yasuaki Kubota, Phuoc Ba Nguyen, Mitsuru Yasuda, Takashi Deguchi |
Journal | International journal of urology : official journal of the Japanese Urological Association
(Int J Urol)
Vol. 14
Issue 5
Pg. 422-5
(May 2007)
ISSN: 0919-8172 [Print] Australia |
PMID | 17511725
(Publication Type: Journal Article)
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Chemical References |
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Topics |
- Adolescent
- Adult
- Anti-Bacterial Agents
(therapeutic use)
- Chlamydia trachomatis
- Humans
- Male
- Middle Aged
- Mycoplasma genitalium
- Mycoplasma hominis
- Neisseria gonorrhoeae
- Ureaplasma
- Ureaplasma urealyticum
- Urethritis
(drug therapy)
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