Abstract | INTRODUCTION: Fatalities due to mushroom poisonings are increasing worldwide, with more than 90% of deaths resulting from ingestion of amatoxin-containing species. METHODS: RESULTS: The clinical data of 111 patients were evaluated; their biological parameters were monitored every 12-24 hours until discharge. Two patients died; both were admitted to the hospital more than 60 hours after mushroom ingestion. Of all the laboratory parameters evaluated, the evolution of hepatic transaminases and prothrombin activity over four days were the most predictive indicators of recovery or death. Our follow-up evaluation of 105 patients demonstrated that our survivors recovered completely. CONCLUSIONS: Our experience indicates that the protocol used in our Toxicologicy Unit is effective for amatoxin poisoning, and that all patients treated within 36 hours after mushroom ingestion were cured without sequelae.
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Authors | Lucia Giannini, Alfredo Vannacci, Andrea Missanelli, Rosanna Mastroianni, Pier Francesco Mannaioni, Flavio Moroni, Emanuela Masini |
Journal | Clinical toxicology (Philadelphia, Pa.)
(Clin Toxicol (Phila))
2007 Jun-Aug
Vol. 45
Issue 5
Pg. 539-42
ISSN: 1556-3650 [Print] England |
PMID | 17503263
(Publication Type: Journal Article)
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Chemical References |
- Amanitins
- amatoxin
- Aspartate Aminotransferases
- Alanine Transaminase
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Topics |
- Adolescent
- Adult
- Aged
- Aged, 80 and over
- Alanine Transaminase
(blood)
- Amanitins
(poisoning, urine)
- Aspartate Aminotransferases
(blood)
- Female
- Follow-Up Studies
- Hospitalization
- Humans
- Italy
(epidemiology)
- Male
- Middle Aged
- Mushroom Poisoning
(blood, epidemiology, therapy, urine)
- Prognosis
- Prothrombin Time
- Time Factors
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