Glucose-6-phosphate dehydrogenase variants and sickle cell genes in Al-Qunfuda, Saudi Arabia.

Abstract

This study was conducted on 823 male and female subjects to determine the frequency of glucose-6-phosphate dehydrogenase (G-6-PD) deficiency and sickle cell gene in Al-Qunfuda, a densely populated and malaria endemic region in western Saudi Arabia. The results show the presence of both sickle cell and G-6-PD deficiency genes in this population. The prevalence of Hb S heterozygotes in the total population was 18.93% and that of homozygotes was 2.02%. The gene frequency of sickle cell gene was 0.121. G-6-PD-B+ was the normal enzyme and occurred at a frequency of 83.60% and 78.46% in the male and female population, respectively. G-6-PD variants identified included G-6-PD Mediterranean, G-6-PD-A+, G-6-PD-A- and G-6-PD-Mediterranean-like. The frequency of each variant in the male and female population was 10.65% and 9.74% for G-6-PD-Mediterranean, 2.30% and 1.53% for G-6-PD-A+, 0.46% and 0.51% for G-6-PD-A- and 3.0% and 9.74% for the G-6-PD-Mediterranean-like variants, respectively. No significant interaction between sickle cell and G-6-PD genes could be demonstrated.

• Authors: M A el-Hazmi, A S Warsy
• Journal: Tropical and geographical medicine (Trop Geogr Med) 1991 Jan-Apr Vol. 43 Issue 1-2 Pg. 174-9 ISSN: 0041-3232 [Print] Netherlands
• PMID: 1750111 (Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Hemoglobin, Sickle

Topics

• Female
• Glucosephosphate Dehydrogenase Deficiency (ethnology, genetics)
• Hemoglobin, Sickle (genetics)
• Heterozygote
• Humans
• Malaria (ethnology)
• Male
• Phenotype
• Saudi Arabia (epidemiology)