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The preventative role of growth hormone on acute liver injury induced by cardiopulmonary bypass in a rat model.

AbstractOBJECTIVE:
Cardiopulmonary bypass (CPB)-induced acute liver injury is a life-threatening complication after cardiac surgery and is thought to be associated with inflammatory response and acute-phase response (APR). Recombinant human growth hormone (rhGH) can modulate the APR and inflammatory response. Here, we tested the protective effect of GH on CPB-induced liver injury in the rat.
METHODS:
Adult male Sprague-Dawley rats (group G, received 2.5 mg/kg of rhGH intramuscularly at 8a.m. every 24h for 3 days and just before the initiation of CPB; group C served as control) underwent CPB (120 min, 120 ml/kg per minute, 34 degrees C) and were killed 3h after the termination of CPB.
RESULTS:
Administration of rhGH markedly increased serum insulin-like growth factor (IGF)-I and IGF-I-binding protein (IGFBP)-3 compared with group C. Group G showed significantly lower serum concentrations of alanine aminotransferase and total bilirubin after CPB termination. Those receiving rhGH demonstrated a significant increase in serum prealbumin and serum transferrin and a marked decrease in serum amyloid A and serum C-reactive protein compared with group C. rhGH significantly decreased serum tumor necrosis factor-alpha (TNF-alpha) and interleukin-1beta (IL-1beta), whereas no changes were found for serum IL-6 and IL-10 compared with group C. rhGH significantly increased total liver protein content, hepatocyte proliferation, and decreased hepatocyte apoptosis versus group C.
CONCLUSIONS:
These results suggest that GH administration in rats seems to play a preventative role in acute liver injury associated with CPB via the decrease in acute-phase proteins, proinflammatory cytokines TNF-alpha and IL-1beta, and hepatocyte apoptosis, which is associated with increase in constitutive hepatic proteins, total liver protein content, and hepatocyte proliferation.
AuthorsYong An, Ying-Bin Xiao
JournalEuropean journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery (Eur J Cardiothorac Surg) Vol. 31 Issue 6 Pg. 1037-43 (Jun 2007) ISSN: 1010-7940 [Print] Germany
PMID17498965 (Publication Type: Journal Article)
Chemical References
  • Acute-Phase Proteins
  • Carrier Proteins
  • Cytokines
  • Insulin-Like Growth Factor Binding Protein 3
  • Recombinant Proteins
  • Human Growth Hormone
  • Insulin-Like Growth Factor I
  • somatotropin-binding protein
Topics
  • Acute Disease
  • Acute-Phase Proteins (analysis)
  • Acute-Phase Reaction (immunology)
  • Animals
  • Apoptosis (immunology)
  • Cardiopulmonary Bypass (adverse effects)
  • Carrier Proteins (blood)
  • Cell Division (immunology)
  • Cytokines (blood)
  • Disease Models, Animal
  • Human Growth Hormone (administration & dosage, blood)
  • Immunohistochemistry (methods)
  • Injections, Intramuscular
  • Insulin-Like Growth Factor Binding Protein 3 (blood)
  • Insulin-Like Growth Factor I (analysis)
  • Liver (immunology, pathology, physiopathology)
  • Liver Diseases (etiology, immunology, prevention & control)
  • Male
  • Rats
  • Rats, Sprague-Dawley
  • Recombinant Proteins (administration & dosage, blood)

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