Low dose intradermal vaccination is superior to high dose intramuscular vaccination for hepatitis B in unresponsive hemodialysis patients.

Abstract

After two intramuscular (IM) vaccination protocols (40 microg at 0, 1, 2, and 6 months), patients who were unresponsive to hepatitis B vaccination were collected from three HD centers. The aim of this study was to compare the effectiveness of intradermal (ID) and repeated IM vaccination protocols. Thirty-three of 639 HD patients were found to be unresponsive. Patients were randomly assigned into two groups: one to receive 80 microg ID and the other 160 microg IM vaccination protocol. Both ID (p = 0.000) and IM (p = 0.03) groups disclosed statistically significant seroconversion rates six months after the last vaccination dose. The seroconversion rate was 94.1% in the ID and 50% in the IM groups - showing a significant improvement in the ID group (p = 0.011). A low-dose ID is superior to standard IM vaccination protocol and also more cost-effective in unresponsive HD patients.

• Authors: Hasan Micozkadioglu, Aysegul Zumrutdal, Dilek Torun, Siren Sezer, Fatma Nurhan Ozdemir, Mehmet Haberal
• Journal: Renal failure (Ren Fail) Vol. 29 Issue 3 Pg. 285-8 ( 2007) ISSN: 0886-022X [Print] England
• PMID: 17497441 (Publication Type: Comparative Study, Journal Article, Randomized Controlled Trial)

Chemical References

• Biomarkers
• Hepatitis B Antibodies
• Hepatitis B Surface Antigens
• Hepatitis B Vaccines

Topics

• Adult
• Aged
• Biomarkers (blood)
• Cost-Benefit Analysis
• Dose-Response Relationship, Drug
• Female
• Hepatitis B (blood, etiology, prevention & control)
• Hepatitis B Antibodies (blood)
• Hepatitis B Surface Antigens (blood)
• Hepatitis B Vaccines (administration & dosage, economics, therapeutic use)
• Humans
• Injections, Intradermal (adverse effects, economics)
• Injections, Intramuscular (adverse effects, economics)
• Kidney Failure, Chronic (therapy)
• Male
• Middle Aged
• Renal Dialysis
• Research Design
• Treatment Outcome
• Turkey
• Vaccination