Abstract | INTRODUCTION: MATERIAL AND METHODS: 41 Cases of nasopharyngeal masses were obtained from the files at pathology department, Mansoura Faculty of Medicine through the period from 2002 till 2006. 31 cases were corresponded histomorphologically to low-grade B-cell lymphoma of mucosa-associated lymphoid tissue (MALT) type and 10 patients with reactive lymphoid hyperplasia of the adenoid. Hematoxylin- eosin-stained slides were reviewed to confirm the diagnosis. Immunohistochemical studies were performed on formalin-fixed, paraffin-embedded sections using the labeled streptavidin- biotin- peroxidase complex method with DAB as chromogen. The following antibodies were evaluated CD20, CD3, Kappa, lambda and cytokeratin antibodies. RESULTS: All cases of low grade MALT lymphoma show lymphoepithelial lesion and proliferation of centrocyte like cells. 14 cases (45.1%) show subepithelial plasma cells. Dutcher bodies were demonstrated in 10 cases (32.2%). Monocytoid B-cells were seen in 12 cases (38.7%). Six (60%) out of the ten cases of adenoids show transmigrating lymphocyte without formation of lymphoepithelial lesion. All cases with MALT-type lymphoma expressed CD20 and not CD3 whereas 10 cases of adenoid, all expressed B and T cell markers. Immunohistochemical staining showed that 31 cases of low grade MALT lymphoma were positive for immunoglobin light chain (kappa or lambda) while 10 cases of adenoid were positive for both kappa and lambda light chain. CONCLUSION:
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Authors | Amira Kamal El-Hawary |
Journal | Journal of the Egyptian National Cancer Institute
(J Egypt Natl Canc Inst)
Vol. 18
Issue 2
Pg. 103-8
(Jun 2006)
ISSN: 1110-0362 [Print] England |
PMID | 17496934
(Publication Type: Journal Article)
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Topics |
- Adult
- Aged
- Female
- Humans
- Immunohistochemistry
- Lymphoma, B-Cell, Marginal Zone
(diagnosis, pathology)
- Male
- Nasopharyngeal Neoplasms
(diagnosis, pathology)
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