The study was aimed to investigate the changes of
blood coagulation factors during
hemorrhagic shock in rats and the effects of various of
resuscitation fluids on expression of
blood coagulation factors in rats with
hemorrhagic shock and to clarify its possible mechanism. 50 SD rats were randomly divided into 5 groups: control,
sham operation,
shock,
resuscitation 1 (infusion with
Ringer's lactate) and
resuscitation 2 (infusion with 6%
VOLUVEN), 10 rats per group. The rats in
resuscitation 1 and
resuscitation 2 groups were subjected to
hemorrhagic shock, after
hemorrhage shock for 1 hour
resuscitation was performed with
Ringer's lactate and 6%
VOLUVEN. After
resuscitation for 2 hours the changes of t-PA,
PAI-1, TF were measured. At the same time, the rats in
shock and the
sham operation groups were blooded out so as to test. The results showed that the levels of plasma t-PA, t-PA/PAI, TF in the
shock and
resuscitation 1 groups were significantly higher than that in control and
sham operation groups (P<0.01). The levels of plasma t-PA, t-PA/PAI in
resuscitation 1 group were higher than that in
shock group (P<0.01), the levels of plasma t-PA, t-PA/PAI and TF in the
resuscitation 2 group were significantly lower than that in
shock and
resuscitation 1 groups (P<0.01). It is concluded that
hemorrhagic shock may trigger the coagulation cascade reaction, results in hyperfunctioning of fiberinolysis and activation of platelets and coagulation system, and so the
coagulation factor is greatly consumed. Unbalance of coagulation system plays an important role in the progress of
shock. Efficacy of
resuscitation with 6%
VOLUVEN plus
Ringer's lactate may be better than
Ringer's lactate alone in regulating blood coagulation after
hemorrhagic shock in rats.