Abstract | PURPOSE: METHODS: This prospective, randomized, masked study comprised 90 eyes of 90 patients scheduled for phacoemulsification. The patients were divided into three groups (group 1 = without exfoliation, group 2 = with exfoliation syndrome, group 3 = exfoliation syndrome + bimatoprost). Immediately after phacoemulsification, one drop of bimatoprost was instilled in eyes in group 3. Baseline IOP was measured 1 day before surgery and routine follow-ups were performed at 6 hours, 20-24 hours and 1 week postoperatively. RESULTS: Preoperative IOP was 15.0 +/- 2.7 mmHg in group 1, 15.6 +/- 3.2 mmHg in group 2 and 16.1 +/- 3.2 mmHg in group 3 (p = 0.372). Six hours postoperatively, there was a significant difference between the groups (p = 0.013): IOP in group 2 (22.4 +/- 7.3 mmHg) was higher than in group 1 (18.4 +/- 4.4 mmHg) (p = 0.018) and group 3 (18.9 +/- 4.9 mmHg) (p = 0.044). In all groups, IOP values at 6 hours postoperatively were higher than preoperative values (p < 0.001), but IOP values at 20-24 hours and 1 week after surgery were not significantly different from baseline values (p > 0.05). The change in IOP in group 2, from baseline to 6 hours postoperatively, was greater than the equivalent changes in group 1 (p = 0.048) and group 3 (p = 0.016). CONCLUSIONS: Transient IOP increase and spikes were more common in eyes with exfoliation syndrome. Postoperative application of bimatoprost was effective in reducing IOP and preventing IOP spikes >/= 30 mmHg in eyes with exfoliation syndrome in the early postoperative period.
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Authors | Tamer Takmaz, Izzet Can, Canan Gürdal, Piraye Kürkçüoğlu, Senay Aşik |
Journal | Acta ophthalmologica Scandinavica
(Acta Ophthalmol Scand)
Vol. 85
Issue 3
Pg. 262-6
(May 2007)
ISSN: 1395-3907 [Print] Denmark |
PMID | 17488454
(Publication Type: Journal Article, Randomized Controlled Trial)
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Chemical References |
- Amides
- Antihypertensive Agents
- Lipids
- Ophthalmic Solutions
- Cloprostenol
- Bimatoprost
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Topics |
- Aged
- Amides
(administration & dosage)
- Antihypertensive Agents
(administration & dosage)
- Bimatoprost
- Cloprostenol
(administration & dosage, analogs & derivatives)
- Double-Blind Method
- Exfoliation Syndrome
(complications)
- Female
- Humans
- Intraocular Pressure
(drug effects)
- Lens Implantation, Intraocular
- Lipids
(administration & dosage)
- Male
- Ocular Hypertension
(prevention & control)
- Ophthalmic Solutions
(administration & dosage)
- Phacoemulsification
- Postoperative Care
- Prospective Studies
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