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Effect of bimatoprost on intraocular pressure after phacoemulsification in eyes with exfoliation syndrome.

AbstractPURPOSE:
To evaluate the effect of bimatoprost 0.03% on intraocular pressure (IOP) after phacoemulsification in eyes with exfoliation syndrome.
METHODS:
This prospective, randomized, masked study comprised 90 eyes of 90 patients scheduled for phacoemulsification. The patients were divided into three groups (group 1 = without exfoliation, group 2 = with exfoliation syndrome, group 3 = exfoliation syndrome + bimatoprost). Immediately after phacoemulsification, one drop of bimatoprost was instilled in eyes in group 3. Baseline IOP was measured 1 day before surgery and routine follow-ups were performed at 6 hours, 20-24 hours and 1 week postoperatively.
RESULTS:
Preoperative IOP was 15.0 +/- 2.7 mmHg in group 1, 15.6 +/- 3.2 mmHg in group 2 and 16.1 +/- 3.2 mmHg in group 3 (p = 0.372). Six hours postoperatively, there was a significant difference between the groups (p = 0.013): IOP in group 2 (22.4 +/- 7.3 mmHg) was higher than in group 1 (18.4 +/- 4.4 mmHg) (p = 0.018) and group 3 (18.9 +/- 4.9 mmHg) (p = 0.044). In all groups, IOP values at 6 hours postoperatively were higher than preoperative values (p < 0.001), but IOP values at 20-24 hours and 1 week after surgery were not significantly different from baseline values (p > 0.05). The change in IOP in group 2, from baseline to 6 hours postoperatively, was greater than the equivalent changes in group 1 (p = 0.048) and group 3 (p = 0.016).
CONCLUSIONS:
Transient IOP increase and spikes were more common in eyes with exfoliation syndrome. Postoperative application of bimatoprost was effective in reducing IOP and preventing IOP spikes >/= 30 mmHg in eyes with exfoliation syndrome in the early postoperative period.
AuthorsTamer Takmaz, Izzet Can, Canan Gürdal, Piraye Kürkçüoğlu, Senay Aşik
JournalActa ophthalmologica Scandinavica (Acta Ophthalmol Scand) Vol. 85 Issue 3 Pg. 262-6 (May 2007) ISSN: 1395-3907 [Print] Denmark
PMID17488454 (Publication Type: Journal Article, Randomized Controlled Trial)
Chemical References
  • Amides
  • Antihypertensive Agents
  • Lipids
  • Ophthalmic Solutions
  • Cloprostenol
  • Bimatoprost
Topics
  • Aged
  • Amides (administration & dosage)
  • Antihypertensive Agents (administration & dosage)
  • Bimatoprost
  • Cloprostenol (administration & dosage, analogs & derivatives)
  • Double-Blind Method
  • Exfoliation Syndrome (complications)
  • Female
  • Humans
  • Intraocular Pressure (drug effects)
  • Lens Implantation, Intraocular
  • Lipids (administration & dosage)
  • Male
  • Ocular Hypertension (prevention & control)
  • Ophthalmic Solutions (administration & dosage)
  • Phacoemulsification
  • Postoperative Care
  • Prospective Studies

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