Predictive value of vascular endothelial growth factor-C expression for local recurrence of rectal carcinoma.
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| Abstract |
Vascular endothelial growth factor-C (VEGF-C) is considered to be a specific factor promoting lymphangiogenesis. There have been reports of a positive correlation between local recurrence of rectal carcinoma and lymphatic invasion by the tumor. The aim of this study was to determine the clinical significance of VEGF-C expression for identifying lymphangiogenesis as a predictor of the local recurrence of rectal carcinoma. One hundred surgical specimens of rectal carcinoma from patients with (n=26) or without (n=74) local recurrence were studied. VEGF-C protein expression was assessed immunohistochemically. The correlations between VEGF-C expression, various clinicopathologic factors, the microscopic lymphatic vessel density (MLVD), and lymphatic invasion were studied. The MLVD (determined by immunohistostaining for D2-40) was significantly higher in VEGF-C positive tumors than VEGF-C negative tumors. VEGF-C positivity was only correlated with lymphatic involvement. Moreover, multivariate analysis showed that VEGF-C protein expression was an independent risk factor for the local recurrence of rectal carcinoma, and patients with VEGF-C positive tumors had a significantly worse prognosis than those with VEGF-C negative tumors. Expression of VEGF-C may be a good predictor of the local recurrence of rectal carcinoma and may also be a useful prognostic indicator.
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| Authors | Eiji Noda, Kiyoshi Maeda, Toru Inoue, Tamahiro Nishihara, Yukio Nishiguchi, Masaichi Ohira, Kosei Hirakawa |
| Journal | Oncology reports (Oncol Rep) Vol. 17 Issue 6 Pg. 1327-31 (Jun 2007) ISSN: 1021-335X [Print] Greece |
| PMID | 17487386 (Publication Type: Journal Article) |
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