Efficacy of voriconazole in a murine model of cryptococcal central nervous system infection.

Abstract

OBJECTIVES:

We studied the efficacy of voriconazole compared with amphotericin B in a murine model of central nervous system infection by Cryptococcus neoformans. Infection was established intracerebrally.

METHODS:

Mice were treated with voriconazole at 10, 40 or 60 mg/kg/day orally or with amphotericin B at 1.5 mg/kg/day intraperitoneally. Treatment began 1 day after infection and continued for 10 days post-infection. Tissue burden studies were performed on day 7 and 1 day after the treatment finished.

RESULTS:

Both drugs were able to significantly prolong survival with respect to the control group. The highest tissue burden reduction was achieved with voriconazole at 60 mg/kg/day.

CONCLUSIONS:

We have developed a murine model of cryptococcal central nervous system infection and demonstrated that voriconazole has a potential for the treatment of cryptococcosis.

• Authors: Carolina Serena, F Javier Pastor, Marçal Mariné, M Mar Rodríguez, Josep Guarro
• Journal: The Journal of antimicrobial chemotherapy (J Antimicrob Chemother) Vol. 60 Issue 1 Pg. 162-5 (Jul 2007) ISSN: 0305-7453 [Print] England
• PMID: 17483143 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Antifungal Agents
• Pyrimidines
• Triazoles
• Voriconazole

Topics

• Animals
• Antifungal Agents (therapeutic use)
• Brain (microbiology)
• Central Nervous System Fungal Infections (drug therapy, microbiology, mortality)
• Cryptococcosis (drug therapy, microbiology, mortality)
• Cryptococcus neoformans (drug effects)
• Disease Models, Animal
• Humans
• Lung (microbiology)
• Male
• Mice
• Pyrimidines (therapeutic use)
• Treatment Outcome
• Triazoles (therapeutic use)
• Voriconazole