Lipoprotein lipase gene PvuII polymorphism serum lipids and risk for coronary artery disease: meta-analysis.

Abstract

Our aim was to determine whether lipoprotein lipase gene PvuII polymorphism can be considered as an independent risk factor for coronary artery disease (CAD) by conducting a meta-analysis of all available published trials, including our own study. In 7 seperate studies, 3289 subjects were screened for this substitution; meta-analysis included only some of these individuals. Among the 7 studies, 6 were performed on white subjects, whereas 1 was on patients with Saudi Arabic descent.Subgroup analysis indicated that individuals with PvuII substitution does not have an increased risk for CAD. The LPL-PvuII genotype and allele frequency distributions did not differ significantly between CAD patients and healthy controls. There was no difference in the distribution of LPL-PvuII genotypes between the healthy subjects and the patients with CAD. However, no significant differences in lipid variables (triglyceride and HDL-cholesterol) were determined for the PvuII polymorphisms in the patients with CAD. No significant differences were found in serum triglyceride and HDL-cholesterol levels for LPL-PvuII genotypes when the control and CAD groups were pooled. In conclusion, LPL-Pvu II polymorphism cannot be used as independent genetic risk factor for CAD.

• Authors: Penbe Cagatay, Belgin Susleyici-Duman, Cavlan Ciftci
• Journal: Disease markers (Dis Markers) Vol. 23 Issue 3 Pg. 161-6 ( 2007) ISSN: 0278-0240 [Print] United States
• PMID: 17473385 (Publication Type: Journal Article, Meta-Analysis)

Chemical References

• Lipids
• Lipoprotein Lipase
• CAGCTG-specific type II deoxyribonucleases
• Deoxyribonucleases, Type II Site-Specific

Topics

• Case-Control Studies
• Coronary Artery Disease (blood, genetics)
• Deoxyribonucleases, Type II Site-Specific
• Genetic Predisposition to Disease
• Humans
• Lipids (blood)
• Lipoprotein Lipase (genetics)
• Polymorphism, Genetic