HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

Assessment of single versus twice daily dosing of ramipril by ambulatory blood pressure monitoring in patients similar to those included in the HOPE study.

Abstract
Ramipril has been used in twice daily dose of 5 mg in most heart failure trials, whereas the dose used in Heart Outcomes Prevention Evaluation (HOPE) study was 10 mg once at bedtime. The HOPE investigators in an ambulatory blood pressure (ABP) substudy observed a fall of nighttime but not daytime blood pressure (BP). We examined the effects of once daily ramipril 10 mg versus 5 mg twice a day. Twenty-nine patients were recruited based on the original criteria for the HOPE study and were given ramipril either in twice-daily dose (5 mg b.d.) or once daily (10 mg o.d.) each morning in randomized, prospective crossover trial. Twenty-four hour ABP recordings were taken just before commencement of ramipril therapy and after treatment with twice-daily and once-daily ramipril. Our results show that ramipril causes a significant reduction of BP over 24-h period as compared with baseline. The mean baseline ABP was 124/73 mm Hg, which reduced to 117/69 mm Hg for the twice-a-day regimen (P<0.001) and 115/68 mm Hg for the once a day regimen (P<0.001). Both regimes effectively lower BP to a similar extent. Ramipril causes significant BP reduction in both once- and twice-daily dosing. The fall in BP after daytime dosing is greater than that observed in the HOPE study (including ABP substudy). Once-daily dosing in the morning seems to be effective in causing a significant reduction in the ABP profile of patients at high-risk of a future vascular event.
AuthorsD Goyal, A Y Chong, R L Watson, N Prasad, R D Watson
JournalJournal of human hypertension (J Hum Hypertens) Vol. 21 Issue 7 Pg. 525-30 (Jul 2007) ISSN: 0950-9240 [Print] England
PMID17460714 (Publication Type: Journal Article, Randomized Controlled Trial)
Chemical References
  • Angiotensin-Converting Enzyme Inhibitors
  • Ramipril
Topics
  • Aged
  • Angiotensin-Converting Enzyme Inhibitors (administration & dosage)
  • Blood Pressure (drug effects)
  • Blood Pressure Monitoring, Ambulatory
  • Cardiovascular Diseases (drug therapy)
  • Cross-Over Studies
  • Diabetes Mellitus (drug therapy)
  • Female
  • Humans
  • Male
  • Middle Aged
  • Prospective Studies
  • Ramipril (administration & dosage)

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: