Ten-year antibody persistence induced by hepatitis A and B vaccine (Twinrix) in adults.

Abstract

BACKGROUND:

Hepatitis A and B infections are prevalent worldwide and cause significant morbidity and mortality. A combined vaccine providing dual protection against hepatitis A and B is available (Twinrix, GlaxoSmithKline Biologicals).

METHOD:

Two cohorts of adults aged 17-43 years were vaccinated with Twinrix according to a 0, 1, 6 months schedule and followed up for 10 years.

RESULTS:

One month after the primary vaccination course (Month 7), all subjects were seropositive for anti-HAV and all had anti-HBs> or = 10 mIU/ml. At month 120, 100% of subjects (N=34; N=29) in both cohorts were seropositive for anti-HAV; 94.1% and 86.2% of subjects had anti-HBs > or = 10 mIU/ml. The geometric mean concentrations (GMC; mIU/ml) were 373.9 and 674.6 in the two cohorts for anti-HAV, and 103.8 and 320.0, respectively, for anti-HBs. None of the serious adverse events reported throughout the follow-up period were considered by the investigator to be causally related to vaccination.

CONCLUSIONS:

Combined hepatitis A and B vaccine, Twinrix, is safe, well-tolerated and has demonstrated a highly immunogenic profile. Persistence of anti-HAV and anti-HBs antibodies in adults remains high for at least 10 years after primary vaccination.

• Authors: K Van Herck, G Leroux-Roels, P Van Damme, K Srinivasa, B Hoet
• Journal: Travel medicine and infectious disease (Travel Med Infect Dis) Vol. 5 Issue 3 Pg. 171-5 (May 2007) ISSN: 1477-8939 [Print] Netherlands
• PMID: 17448944 (Publication Type: Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)

Chemical References

• Hepatitis A Vaccines
• Hepatitis Antibodies
• Hepatitis B Vaccines
• Vaccines, Combined
• twinrix

Topics

• Adolescent
• Adult
• Cohort Studies
• Double-Blind Method
• Female
• Hepatitis A (blood, prevention & control)
• Hepatitis A Vaccines (immunology)
• Hepatitis Antibodies (blood)
• Hepatitis B (blood, prevention & control)
• Hepatitis B Vaccines (immunology)
• Humans
• Male
• Middle Aged
• Travel
• Treatment Outcome
• Vaccination
• Vaccines, Combined (immunology)